Simvastatin (sodium salt)

Cayman Chemical Item Number 10010345

Zocor™ (CAS 101314-97-0)

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HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.2 Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe (Zetia) to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy. In dogs, after 18 days of treatment with simvastatin at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.3 Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.4

1. Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2 517-526 (2003).

2. Corsini, A., Maggi, F.M., and Catapano, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res 31(1) 9-27 (1995).

3. Chao, Y., Chen, J.S., Hunt, V.M., et al. Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin. Eur J Clin Pharmacol 40 S11-S14 (1991).

4. Ahn, K.S., Sethi, G., and Aggarwal, B.B. Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway. Biochem Pharmacol 75 907-913 (2008).

  • Zocor™
Formal Name (βR,​δR,​1S,​2S,​6R,​8S,​8aR)-​8-​(2,​2-​dimethyl-​1-​oxobutoxy)-​1,​2,​6,​7,​8,​8a-​hexahydro-​β,​δ-​dihydroxy-​2,​6-​dimethyl-​1-​naphthaleneheptanoic acid,​ monosodium salt
CAS Number 101314-97-0
Molecular Formula C25H39O6 • Na
Formula Weight 458.6
Formulation A crystalline solid
Purity ≥98%
λmax 231, 238, 246 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $28.00 $0.00
5 mg $126.00 $0.00
10 mg $224.00 $0.00
25 mg $490.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Ann Arbor, Michigan 48108 USA


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