Cayman is a manufacturer, supplier, and vendor of biochemical reagents,
assay kits, forensic chemistry standards, antibodies, and proteins for
scientific research. Analytical testing services and custom synthesis are
Cayman Chemical Company
· 1180 East Ellsworth Road
· Ann Arbor, Michigan 48108
HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.2 Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe (Zetia) to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy. In dogs, after 18 days of treatment with simvastatin at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.3 Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.4
1.Tobert, J.A.Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov2517-526(2003).
2.Corsini, A., Maggi, F.M., and Catapano, A.L.Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res31(1)9-27(1995).
3.Chao, Y., Chen, J.S., Hunt, V.M., et al. Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin. Eur J Clin Pharmacol40S11-S14(1991).
4.Ahn, K.S., Sethi, G., and Aggarwal, B.B.Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway. Biochem Pharmacol75907-913(2008).
(βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monosodium salt
C25H39O6 • Na
A crystalline solid
231, 238, 246 nm
in continental US; may vary elsewhere
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.