AL 8810 ethyl amide

Cayman Chemical Item Number 10010470

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AL 8810 is an 11β-fluoro analog of prostaglandin F (PGF) which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 ethyl amide is an analog of AL 8810 in which the C-1 carboxyl group has been modified to an N-ethyl amide. This modification is analogous to the PG N-ethyl amides, as typified by Bimatoprost, that have been introduced as alternative PG ocular hypotensive prodrugs.2 In contrast to AL 8810 which contracted the cat iris, AL 8810 ethyl amide showed no contraction activity at concentrations up to 10-4 M and did not antagonize the activity of PGF-ethanolamide in this system.3

1. Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F analog with selective antagonist effects at the prostaglandin F (FP) receptor. J Pharmacol Exp Ther 290(3) 1278-1284 (1999).

2. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Surv Ophthalmol 45 S337-S345 (2001).

3. Woodward, D.F., Krauss, A.H., Wang, J.W., et al. Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris. Br J Pharmacol 150 342-352 (2007).

Formal Name 9α,​15R-​dihydroxy-​11β-​fluoro-​15-​92,​3-​dihydro-​1H-​inden-​2-​yl)-​16,​17,​18,​19,​20-​pentanor-​prosta-​5Z,​13E-​dion-​1-​oic acid,​ ethyl amide
Molecular Formula C26H36FNO3
Formula Weight 429.6
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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AL 8810 ethyl amide is available in the following screening library:

Size Price Quantity Subtotal
1 mg $61.00 $0.00
5 mg $275.00 $0.00
10 mg $488.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

AL 8810
AL 8810 isopropyl ester
AL 8810 methyl ester


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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


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