BIBB 515

Cayman Chemical Item Number 10010517

(CAS 156635-05-1)

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2,3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.1

1. Eisele, B., Budzinski, R., Müller, P., et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. J Lipid Res 38 564-574 (1997).

Formal Name 1-​(4-​chlorobenzoyl)-​4-​[[4-​(4,​5-​dihydro-​2-​oxazolyl)phenyl]methylene]-​piperidine
CAS Number 156635-05-1
Molecular Formula C22H21ClN2O2
Formula Weight 380.9
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
5 mg $35.00 $0.00
10 mg $60.00 $0.00
50 mg $245.00 $0.00
100 mg $385.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-01. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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