Cayman is a manufacturer, supplier, and vendor of biochemical reagents,
assay kits, forensic chemistry standards, antibodies, and proteins for
scientific research. Analytical testing services and custom synthesis are
Cayman Chemical Company
· 1180 East Ellsworth Road
· Ann Arbor, Michigan 48108
PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1.1 It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits 2,1 and reduces oxidant stress-induced apoptosis in endothelial cells.3 PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.4 In addition, it lacks significant non-specific antioxidant properties.2
1.Bocan, T.M.A., Rosebury, W.S., Mueller, S.B., et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis136203-216(1998).
2.Sendobry, S.M., Cornicelli, J.A., Welch, K., et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol1201199-1206(1997).
3.Sordillo, L.M., Weaver, J.A., Cao, Y., et al. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat7619-34(2005).
4.Succol, F., and Praticò, D.A role for 12/15 lipoxygenase in the amyloid b precursor protein metabolism. J Neurochem103380-387(2007).
A crystalline solid
in continental US; may vary elsewhere
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.