PD 146176 • NSC 168807 (CAS 4079-26-9) (Inchi key ZGOOPZVQMLHPFM-UHFFFAOYSA-N) || Cayman Chemical | Supplier
PD 146176
Item № 10010518
CAS № 4079-26-9
Purity ≥98%
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5 mg $38.00 $0.00
10 mg $72.00 $0.00
25 mg $171.00 $0.00
50 mg $304.00 $0.00

Pricing updated 2015-09-01. Prices are subject to change without notice.

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Description
Synonyms
  • NSC 168807

PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1.1 It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits 2,1 and reduces oxidant stress-induced apoptosis in endothelial cells.3 PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.4 In addition, it lacks significant non-specific antioxidant properties.2

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Technical Information
Formal Name 6,​11-​dihydro-​[1]benzothiopyrano[4,​3-​b]indole
CAS Number 4079-26-9
Synonyms
  • NSC 168807
Molecular Formula C15H11NS
Formula Weight 237.3
Purity ≥98%
Formulation A crystalline solid
SMILES c1ccc2c(c1)​SCc1c2[nH]​c2ccccc12
InChI Code ​1S/C15H11NS/c1-3-7-13-10(5-1)​12-9-17-14-8-4-2-6-11(14)​15(12)​16-13/h1-8,16H,9H2
InChI Key ZGOOPZVQMLHPFM-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 126 Kb PDF

Download Safety Data Sheet (SDS) 22 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Bocan, T.M.A., Rosebury, W.S., Mueller, S.B., et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis 136 203-216 (1998).

2. Sendobry, S.M., Cornicelli, J.A., Welch, K., et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol 120 1199-1206 (1997).

3. Sordillo, L.M., Weaver, J.A., Cao, Y., et al. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat 76 19-34 (2005).

4. Succol, F., and Praticò, D. A role for 12/15 lipoxygenase in the amyloid b precursor protein metabolism. J Neurochem 103 380-387 (2007).

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