KT 5823
Item № 10010965
CAS № 126643-37-6
Purity ≥95%
product image
25 µg $28.00 $0.00
50 µg $53.00 $0.00
100 µg $101.00 $0.00
250 µg $224.00 $0.00

Pricing updated 2015-11-26. Prices are subject to change without notice.

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The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50 = 234 nM).1 KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells.2 KT 5823 is a weak inhibitor of PKC (Ki = 4 µM) and PKA (Ki >10 µM).1

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Technical Information
Formal Name 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
CAS Number 126643-37-6
Molecular Formula C29H25N3O5
Formula Weight 495.5
Purity ≥95%
Formulation A neat oil
SMILES COC(=O)[C@@]1(OC)C[C@H]2O[C@@]1(C)n1c3ccccc3c3c4CN(C)C(=O)c4c4c5ccccc5n2c4c13
InChI Code 1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29?/m0/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
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Download Product Insert 138 Kb PDF

Download Safety Data Sheet (SDS) 23 Kb PDF

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References & Background Reading
Product Description References

1. Hidaka, H., and Kobayashi, R. Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol 32 377-397 (1992).

2. Burkhardt, M., Glazova, M., Gambaryan, S., et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275(43) 33536-33541 (2000).

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