KT 5823

Cayman Chemical Item Number 10010965

(CAS 126643-37-6)

KT 5823 (CAS 126643-37-6)

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Description

The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of PKG (in vitro IC50 = 234 nM).1 KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells.2 KT 5823 is a weak inhibitor of PKC (Ki = 4 µM) and PKA (Ki >10 µM).1

1 Hidaka, H., and Kobayashi, R. Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol 32 377-397 (1992).

2 Burkhardt, M., Glazova, M., Gambaryan, S., et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275(43) 33536-33541 (2000).

Formal Name 2,​3,​9,​10,​11,​12-​hexahydro-​10R-​methoxy-​2,​9-​dimethyl-​1-​oxo-​9S,​12R-​epoxy-​1H-​diindolo[1,​2,​3-​fg:3’,​2’,​1’-​kl]pyrrolo[3,​4-​i][1,​6]benzodiazocine-​10-​carboxylic acid,​ methyl ester
CAS Number 126643-37-6
Molecular Formula C29H25N3O5
Formula Weight 495.5
Formulation A neat oil
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COC(=O)​[C@@]​1(OC)​C[C@H]​2O[C@@]​1(C)​n1c3ccccc3c3c4CN(C)​C(=O)​c4c4c5ccccc5n2c4c13
InCHI Code
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​1S/C29H25N3O5/c1-28-29(36-4,27(34)​35-3)​13-20(37-28)​31-18-11-7-5-9-15(18)​22-23-17(14-30(2)​26(23)​33)​21-16-10-6-8-12-19(16)​32(28)​25(21)​24(22)​31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29?/m0/s1
InCHI Key
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QTYMDECKVKSGSM-MCFVQZIUSA-N

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KT 5823 is available in the following screening library:

Size Price Quantity Subtotal
25 µg $28.00 $0.00
50 µg $53.00 $0.00
100 µg $101.00 $0.00
250 µg $224.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-23. Prices are subject to change without notice.

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