KT 5823

Cayman Chemical Item Number 10010965

(CAS 126643-37-6)

See more


The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50 = 234 nM).1 KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells.2 KT 5823 is a weak inhibitor of PKC (Ki = 4 µM) and PKA (Ki >10 µM).1

1. Hidaka, H., and Kobayashi, R. Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol 32 377-397 (1992).

2. Burkhardt, M., Glazova, M., Gambaryan, S., et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275(43) 33536-33541 (2000).

Formal Name 2,​3,​9,​10,​11,​12-​hexahydro-​10R-​methoxy-​2,​9-​dimethyl-​1-​oxo-​9S,​12R-​epoxy-​1H-​diindolo[1,​2,​3-​fg:3’,​2’,​1’-​kl]pyrrolo[3,​4-​i][1,​6]benzodiazocine-​10-​carboxylic acid,​ methyl ester
CAS Number 126643-37-6
Molecular Formula C29H25N3O5
Formula Weight 495.5
Formulation A neat oil
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Copy SMILES to clipboard
InCHI Code
Copy InCHI code to clipboard
Copy InCHI key to clipboard

Download free InCHI Key generation software

Size Price Quantity Subtotal
25 µg $28.00 $0.00
50 µg $53.00 $0.00
100 µg $101.00 $0.00
250 µg $224.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Cyclic GMP EIA Kit
KT 5720
PKG Inhibitor
Show all 7 Hide all but first 3


Batch-specific Information

Get batch-specific data and documents by batch number

Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


Please wait...