Sphingosine-1-phosphate (S1P) modulates skin, vascular endothelial, and immune cells via five distinct G protein-coupled receptors. The S1P type 1 receptor, S1P1, also known as EDG-1, mediates endothelial, lymphoid, and neuronal cell responses to S1P, as well as the synthetic agonist FTY720. W123 is an analog of FTY720 that is a competitive antagonist of S1P1, as measured by GTPγS activation, mitogen-activated protein kinase recruitment, cell migration, and ligand-induced receptor internalization.1 It has a Ki value of 0.69 μM when assessed by SEW2871-induced activation of S1P1.1 Its specificity for other S1P receptor subtypes remains to be determined.
1Wei, S.H., Rosen, H., Matheu, M.P., et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol6(12)1228-1235(2005).
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.
Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research
Analytical testing services and custom synthesis also available