Item № 10010992
CAS № 1345982-24-2
Purity ≥98%
product image
1 mg $64.00 $0.00
5 mg $288.00 $0.00
10 mg $512.00 $0.00
25 mg $1,120.00 $0.00

Pricing updated 2015-11-28. Prices are subject to change without notice.

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Sphingosine-1-phosphate (S1P) modulates skin, vascular endothelial, and immune cells via five distinct G protein-coupled receptors. The S1P type 1 receptor, S1P1, also known as EDG-1, mediates endothelial, lymphoid, and neuronal cell responses to S1P, as well as the synthetic agonist FTY720. W123 is an analog of FTY720 that is a competitive antagonist of S1P1, as measured by GTPγS activation, mitogen-activated protein kinase recruitment, cell migration, and ligand-induced receptor internalization.1 It has a Ki value of 0.69 μM when assessed by SEW2871-induced activation of S1P1.1 Its specificity for other S1P receptor subtypes remains to be determined.

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Technical Information
Formal Name 3-(2-(3-hexylphenylamino)-2-oxoethylamino)propanoic acid
CAS Number 1345982-24-2
Molecular Formula C17H26N2O3
Formula Weight 306.4
Purity ≥98%
Formulation A crystalline solid
λmax 244 nm
InChI Code 1S/C17H26N2O3/c1-2-3-4-5-7-14-8-6-9-15(12-14)19-16(20)13-18-11-10-17(21)22/h6,8-9,12,18H,2-5,7,10-11,13H2,1H3,(H,19,20)(H,21,22)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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Download Product Insert 105 Kb PDF

Download Safety Data Sheet (SDS) 23 Kb PDF

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References & Background Reading
Product Description References

1. Wei, S.H., Rosen, H., Matheu, M.P., et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol 6(12) 1228-1235 (2005).

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