Cayman Chemical Item Number 10011133

NSC 136630 (CAS 58-74-2)

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Papaverine is an opium alkaloid that is structurally and pharmacologically distinct from opiates. At the cellular level, papaverine inhibits phosphodiesterase activity (IC50 = 13 μM).1 Through this action, it increases cellular cAMP levels and alters cellular function. It has been shown to reduce arterial and cerebral vasospasm2,3 and has been used to treat erectile dysfunction.4,5 Papaverine is recommended as a potent nonselective phosphodiesterase inhibitor for in vitro and in vivo research purposes.

1. Davis, C.W. Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxycyclic AMP and potassium ions. Biochem Biophys Acta 797 354-362 (1984).

2. Vardiman, A.B., Kopitnik, T.A., Purdy, P.D., et al. Treatment of traumatic arterial vasospasm with intraarterial papaverine infusion. AJNR Am J Neuroradiol 16 319-321 (1995).

3. Clouston, J.E., Numaguchi, Y., Zoarski, G.H., et al. Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol 16 27-38 (1995).

4. Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

5. Earle, C.M., Keogh, E.J., Wisniewski, Z.S., et al. Prostaglandin E1 therapy for impotence, comparison with papaverine. J Urol 143 57-59 (1990).

  • NSC 136630
Formal Name 1-​[(3,​4-​dimethoxyphenyl)methyl]-​6,​7-​dimethoxy isoquinoline
CAS Number 58-74-2
Molecular Formula C20H21NO4
Formula Weight 339.4
Formulation A crystalline solid
Purity ≥98%
λmax 239 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
100 mg $25.00 $0.00
250 mg $44.00 $0.00
500 mg $63.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-28. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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