Papaverine • NSC 136630 (CAS 58-74-2) (Inchi key XQYZDYMELSJDRZ-UHFFFAOYSA-N) || Cayman Chemical | Supplier
Papaverine
Item № 10011133
CAS № 58-74-2
Purity ≥98%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
100 mg $25.00 $0.00
250 mg $44.00 $0.00
500 mg $63.00 $0.00

Pricing updated 2015-08-28. Prices are subject to change without notice.

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Description
Synonyms
  • NSC 136630

Papaverine is an opium alkaloid that is structurally and pharmacologically distinct from opiates. At the cellular level, papaverine inhibits phosphodiesterase activity (IC50 = 13 μM).1 Through this action, it increases cellular cAMP levels and alters cellular function. It has been shown to reduce arterial and cerebral vasospasm2,3 and has been used to treat erectile dysfunction.4,5 Papaverine is recommended as a potent nonselective phosphodiesterase inhibitor for in vitro and in vivo research purposes.

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Technical Information
Formal Name 1-​[(3,​4-​dimethoxyphenyl)methyl]-​6,​7-​dimethoxy isoquinoline
CAS Number 58-74-2
Synonyms
  • NSC 136630
Molecular Formula C20H21NO4
Formula Weight 339.4
Purity ≥98%
Formulation A crystalline solid
λmax 239 nm
SMILES COc1ccc(cc1OC)​Cc1nccc2cc(OC)​c(OC)​cc12
InChI Code ​1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)​23-2)​9-16-15-12-20(25-4)​19(24-3)​11-14(15)​7-8-21-16/h5-8,10-12H,9H2,1-4H3
InChI Key XQYZDYMELSJDRZ-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Davis, C.W. Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxycyclic AMP and potassium ions. Biochem Biophys Acta 797 354-362 (1984).

2. Vardiman, A.B., Kopitnik, T.A., Purdy, P.D., et al. Treatment of traumatic arterial vasospasm with intraarterial papaverine infusion. AJNR Am J Neuroradiol 16 319-321 (1995).

3. Clouston, J.E., Numaguchi, Y., Zoarski, G.H., et al. Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol 16 27-38 (1995).

4. Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

5. Earle, C.M., Keogh, E.J., Wisniewski, Z.S., et al. Prostaglandin E1 therapy for impotence, comparison with papaverine. J Urol 143 57-59 (1990).

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