Papaverine

Cayman Chemical Item Number 10011133

NSC 136630 (CAS 58-74-2)

Papaverine (CAS 58-74-2)

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Description

Papaverine is an opium alkaloid that is structurally and pharmacologically distinct from opiates. At the cellular level, papaverine inhibits phosphodiesterase activity (IC50 = 13 μM).1 Through this action, it increases cellular cAMP levels and alters cellular function. It has been shown to reduce arterial and cerebral vasospasm2,3 and has been used to treat erectile dysfunction.4,5 Papaverine is recommended as a potent nonselective phosphodiesterase inhibitor for in vitro and in vivo research purposes.

1 Davis, C.W. Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxycyclic AMP and potassium ions. Biochem Biophys Acta 797 354-362 (1984).

2 Vardiman, A.B., Kopitnik, T.A., Purdy, P.D., et al. Treatment of traumatic arterial vasospasm with intraarterial papaverine infusion. AJNR Am J Neuroradiol 16 319-321 (1995).

3 Clouston, J.E., Numaguchi, Y., Zoarski, G.H., et al. Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol 16 27-38 (1995).

4 Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

5 Earle, C.M., Keogh, E.J., Wisniewski, Z.S., et al. Prostaglandin E1 therapy for impotence, comparison with papaverine. J Urol 143 57-59 (1990).

Synonyms
  • NSC 136630
Formal Name 1-​[(3,​4-​dimethoxyphenyl)methyl]-​6,​7-​dimethoxy isoquinoline
CAS Number 58-74-2
Molecular Formula C20H21NO4
Formula Weight 339.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(cc1OC)​Cc1nccc2cc(OC)​c(OC)​cc12
InCHI Code
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​1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)​23-2)​9-16-15-12-20(25-4)​19(24-3)​11-14(15)​7-8-21-16/h5-8,10-12H,9H2,1-4H3
InCHI Key
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XQYZDYMELSJDRZ-UHFFFAOYSA-N

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Size Price Quantity Subtotal
100 mg $25.00 $0.00
250 mg $44.00 $0.00
500 mg $63.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-23. Prices are subject to change without notice.

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