Papaverine is an opium alkaloid that is structurally and pharmacologically distinct from opiates. At the cellular level, papaverine inhibits phosphodiesterase activity (IC50 = 13 μM).1 Through this action, it increases cellular cAMP levels and alters cellular function. It has been shown to reduce arterial and cerebral vasospasm2,3 and has been used to treat erectile dysfunction.4,5 Papaverine is recommended as a potent nonselective phosphodiesterase inhibitor for in vitro and in vivo research purposes.
1Davis, C.W.Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxycyclic AMP and potassium ions. Biochem Biophys Acta797354-362(1984).
2Vardiman, A.B., Kopitnik, T.A., Purdy, P.D., et al. Treatment of traumatic arterial vasospasm with intraarterial papaverine infusion. AJNR Am J Neuroradiol16319-321(1995).
3Clouston, J.E., Numaguchi, Y., Zoarski, G.H., et al. Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol1627-38(1995).
4Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol145287-293(1991).
5Earle, C.M., Keogh, E.J., Wisniewski, Z.S., et al. Prostaglandin E1 therapy for impotence, comparison with papaverine. J Urol14357-59(1990).
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.
Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research
Analytical testing services and custom synthesis also available