N-octanoyl-L-Homoserine lactone
Item № 10011199
CAS № 147852-84-4
Purity ≥98%
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5 mg $31.00 $0.00
10 mg $59.00 $0.00
25 mg $140.00 $0.00
50 mg $248.00 $0.00

Pricing updated 2015-11-28. Prices are subject to change without notice.

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  • C8-HSL
  • OHL

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-octanoyl-L-Homoserine lactone (C8-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism.1,2,3 The applications of this molecule include infection prevention and regulation of virulence in general and in cystic fibrosis.4,5

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Technical Information
Formal Name N-[(3S)-tetrahydro-2-oxo-3-furanyl]-octanamide
CAS Number 147852-84-4
  • C8-HSL
  • OHL
Molecular Formula C12H21NO3
Formula Weight 227.3
Purity ≥98%
Formulation A crystalline solid
InChI Code 1S/C12H21NO3/c1-2-3-4-5-6-7-11(14)13-10-8-9-16-12(10)15/h10H,2-9H2,1H3,(H,13,14)/t10-/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 103 Kb PDF

Download Safety Data Sheet (SDS) 22 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Kuo, A., Blough, N.V., and Dunlap, P.V. Multiple N-acyl-L-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri. J Bacteriol 176(24) 7558-7565 (1994).

2. Lithgow, J.K., Wilkinson, A., Hardman, A., et al. The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum-sensing loci. Mol Microbiol 37(1) 81-97 (2000).

3. McClean, K.H., Winson, M.K., Fish, L., et al. Quorum-sensing and Chromobacterium violaceum: Exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. Microbiology 143 3703-3711 (1997).

4. Riedel, K., Hentzer, M., Geisenberger, O., et al. N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. Microbiology 147 3249-3262 (2001).

5. Winson, M.K., Camara, M., Latifi, A., et al. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa. Proc Natl Acad Sci USA 92 9427-9431 (1995).

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