GW 9578 Exclusive

Cayman Chemical Item Number 10011211

(CAS 247923-29-1)

GW 9578 (CAS 247923-29-1)

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Description

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor found predominantly in the liver that is involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. 3 GW 9578 is a potent agonist of PPARα that activates the murine and human receptors with EC50 values of 0.005 and 0.05 µM, respectively.4 GW 9578 is highly selective for PPARα compared to PPARγ and PPARδ, which it activates in murine at EC50 values of 0.15 and 2.6 µM, respectively and in human at 1.0 and 1.4 µM, respectively.4 GW 9578 is a potent lipid lowering agent that may reduce insulin resistance. When 0.2 mg/kg GW 9578 was given orally once daily for three days, serum total LDL cholesterol was decreased 40-60% in male Sprague-Dawely rats.4 Obese Zucker rats treated with 5 mg/kg GW 9578 for nine days had markedly reduced serum insulin concentrations compared to controls.5

1 Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

2 Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

3 Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci 61 393-416 (2004).

4 Brown, P.J., Winegar, D.A., Plunket, K.D., et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity. J Med Chem 42 3785-3788 (1999).

5 Guerre-Millo, M., Gervois, P., Raspé, E., et al. Peroxisome proliferator-activated receptor a activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275 16638-16642 (2000).

Formal Name 2-​[[4-​[2-​[[[(2,​4-​difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]-​2-​methyl-​propanoic acid
CAS Number 247923-29-1
Molecular Formula C26H34F2N2O3S
Formula Weight 492.6
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCN(CCc1ccc(cc1)​SC(C)​(C)​C(=O)​O)​C(=O)​Nc1ccc(F)​cc1F
InCHI Code
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​1S/C26H34F2N2O3S/c1-4-5-6-7-8-16-30(25(33)​29-23-14-11-20(27)​18-22(23)​28)​17-15-19-9-12-21(13-10-19)​34-26(2,3)​24(31)​32/h9-14,18H,4-8,15-17H2,1-3H3,(H,29,33)​(H,31,32)​
InCHI Key
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KYQNYMXQHLMADB-UHFFFAOYSA-N

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Size Price Quantity Subtotal
500 µg $23.00 $0.00
1 mg $44.00 $0.00
5 mg $184.00 $0.00
10 mg $322.00 $0.00
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Pricing updated 2014-04-24. Prices are subject to change without notice.

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