C-Reactive Protein (human) EIA Kit

Cayman Chemical Item Number 10011236

CRP (human) ELISA Kit

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Description

Limit of detection: 46.9 pg/ml · C-Reactive Protein (CRP) is a 224 amino acid protein that is synthesized primarily by hepatocytes, and to a lesser extent adipocytes. CRP plasma levels increase ~1,000-fold in response to acute and chronic inflammatory conditions, making it a useful gauge of inflammation in a wide range of physiological and pathological conditions.1 Normal levels of serum CRP (0.64 µg/ml) do not differ between healthy adult men and women, but tend to increase slightly with age.2 High plasma CRP concentrations (>3 µg/ml) are associated with an increased risk for atherosclerosis.3 CRP has been implicated as a contributor to atherogenesis by modulating endothelial function, stimulating coagulation, inducing the expression of ICAM-1, VCAM-1, and E-selectin, mediating uptake of LDL into macrophages, and destabilizing plaques.1,4,5,6,7,8,9 In addition, CRP can bind in a calcium-dependent manner to phosphocholine on microbes, act as a ligand for specific receptors on phagocytic leukocytes, mediate activation of monocytes and macrophages via IL-6, TNF-α and other cytokines, and assist in the complement pathway.1,10,11,12 Cayman’s CRP (human) EIA Kit is an immunometric assay which can be used to measure CRP in plasma without prior sample purification. The standard curve spans the range of 0-3,000 pg/ml with a limit of detection of approximately 50 pg/ml.

1. Volanakis, J.E. Human C-reactive protein: expression, structure, and function. Mol Immunol 38 189-197 (2001).

2. Macy, E.M., Hayes, T.E., and Tracy, R.P. Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications. Clin Chem 43(1) 52-58 (1997).

3. Ridker, P.M. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107 363-369 (2003).

4. Pasceri, V., Willerson, J.T., and Yeh, E.T.H. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102 2165-2168 (2000).

5. Tracy, R.P. Inflammation in cardiovascular disease cart, horse, or both? Circulation 97 2000-2002 (1998).

6. Fichtlscherer, S., Rosenberger, G., Walter, D.H., et al. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 102 1000-1006 (2000).

7. Zwaka, T.P., Hombach, V., and Torzewski, J. C-reactive protein-mediated low density lipoprotein uptake by macrophages. Implications for atherosclerosis. Circulation 103 1194-1197 (2001).

8. Howitz, K.T., Bitterman, K.J., Cohen, H.Y., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 191-196 (2003).

9. de Ferranti, S., and Rifai, N. C-reactive protein and cardiovascular disease: a review of risk prediction and interventions. Clin Chim Acta 317 1-15 (2002).

10. Marnell, L.L., Mold, C., Volzer, M.A., et al. C-reactive protein binds to FcgRI in transfected COS cells. J Immunol 155 2185-2193 (1995).

11. Szalai, A.J., van Ginkel, F.W., Wang, Y., et al. Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component. J Immunol 165 1030-1035 (2000).

12. Ganapathi, M.K., Rzewnicki, D., Samols, D., et al. Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in HEP 3B cells. J Immunol 147(4) 1261-1265 (1991).

Synonyms
  • CRP (human) ELISA Kit
Stability 6 months
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere

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Size Price Quantity Subtotal
96 wells $305.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-29. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

You may be eligible to receive a free sample C-Reactive Protein (human) EIA Kit under the Cayman Challenge program.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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