Allopurinol (CAS 315-30-0) (Inchi key OFCNXPDARWKPPY-UHFFFAOYSA-N) || Cayman Chemical | Supplier
Allopurinol
Item № 10012597
CAS № 315-30-0
Purity ≥98%
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25 g $25.00 $0.00
50 g $48.00 $0.00
100 g $90.00 $0.00

Pricing updated 2015-08-30. Prices are subject to change without notice.

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Description

Xanthine oxidoreductase mediates the successive oxidation of hypoxanthine and xanthine to produce uric acid. The enzyme can interconvert between xanthine dehydrogenase and xanthine oxidase activities through reversible sulfhydryl oxidation on specific cysteine residues. Both forms oxidize hypoxanthine and xanthine to uric acid. However the dehydrogenase simultaneously reduces nicotinamide adenine dinucleotide while the oxidase reduces oxygen to superoxide. Allopurinol is an isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM, depending on assay and cell type).1,2 In vivo, allopurinol has been reported to effectively and safely lower serum and urinary uric acid levels and is also reported to be effective in the treatment of gout and hyperuricemia. Allopurinol is rapidly metabolized in vivo to the xanthine analog oxypurinol, which is a metabolite that clearly augments the therapeutic effect of allopurinol.3

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Technical Information
Formal Name 1,​5-​dihydro-​4H-​pyrazolo[3,​4-​d]pyrimidin-​4-​one
CAS Number 315-30-0
Molecular Formula C5H4N4O
Formula Weight 136.1
Purity ≥98%
Formulation A crystalline solid
SMILES O=c1nc[nH]​c2[nH]​ncc12
InChI Code ​1S/C5H4N4O/c10-5-3-1-8-9-4(3)​6-2-7-5/h1-2H,(H2,6,7,8,9,10)​
InChI Key OFCNXPDARWKPPY-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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Download Product Insert 125 Kb PDF

Download Safety Data Sheet (SDS) 28 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Fujimoto, Y., Sakuma, S., Tagami, T., et al. N-ethylmaleimide inhibits xanthine oxidase activity with no detectable change in xanthine dehydrogenase activity in rabbit liver. Life Sci 68 517-524 (2000).

2. Pacher, P., Nivorozhkin, A., and Szabó, C. Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol. Pharmacol Rev 58(1) 87-114 (2006).

3. Day, R.O., Graham, G.G., Hicks, M., et al. Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. Clin Pharmacokinet 46(8) 623-644 (2007).

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