FR122047 (hydrate)

Cayman Chemical Item Number 10039

FR122047 (hydrate)

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Description

FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 µM, respectively.1 In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin.2 Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.3

1 Ochi, T., Motoyama, Y., and Goto, T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol 391 49-54 (2000).

2 Dohi, M., Sakata, Y., Seki, J., et al. The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur J Pharmacol 243 179-184 (1993).

3 Ochi, T., and Goto, T. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br J Pharmacol 135 782-788 (2002).

Formal Name 1-​[[4,​5-​bis(4-​methoxyphenyl)-​2-​thiazolyl]carbonyl]-​4-​methyl-​piperazine,​ monohydrochloride
Molecular Formula C23H25N3O3S · HCl [H2O]
Formula Weight 478.0
Formulation A crystalline solid
Purity ≥98%
λmax 234, 270, 344 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(N1CCN(C)​CC1)​C2=NC(C3=CC=C(OC)​C=C3)​=C(S2)​C4=CC=C(OC)​C=C4.Cl
InCHI Code
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​1S/C23H25N3O3S.ClH.H2O/c1-25-12-14-26(15-13-25)​23(27)​22-24-20(16-4-8-18(28-2)​9-5-16)​21(30-22)​17-6-10-19(29-3)​11-7-17;;/h4-11H,12-15H2,1-3H3;1H;1H2
InCHI Key
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YIENDBRVBWQZAM-UHFFFAOYSA-N

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FR122047 (hydrate) is available in the following screening library:

Size Price Quantity Subtotal
1 mg $14.00 $0.00
5 mg $63.00 $0.00
10 mg $112.00 $0.00
50 mg $490.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-21. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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