15-deoxy-Δ12,14-Prostaglandin A1

Cayman Chemical Item Number 10065

15-deoxy-Δ12,14-PGA1 (CAS 573951-20-9)

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Description

15-deoxy-Δ12,14-Prostaglandin A1 (15-deoxy-Δ12,14-PGA1) is a synthetic PGA1 analog. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.1 Antimitotic and antitumor activity have been reported for a similar analog,2 but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA1 at this time.

1. Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813-819 (1995).

2. Kato, T., Fukushima, M., Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Res 46 3538-3542 (1986).

Synonyms
  • 15-deoxy-Δ12,14-PGA1
Formal Name 9-​oxo-​prosta-​10,​12Z,​14E-​trien-​1-​oic acid
CAS Number 573951-20-9
Molecular Formula C20H30O3
Formula Weight 318.5
Formulation A solution in methyl acetate
Purity >95%
λmax 324 nm
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C/C=C1\C=CC(=O)​C\1CCCCCCC(=O)​O
InCHI Code
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​1S/C20H30O3/c1-2-3-4-5-6-9-12-17-15-16-19(21)​18(17)​13-10-7-8-11-14-20(22)​23/h6,9,12,15-16,18H,2-5,7-8,10-11,13-14H2,1H3,(H,22,23)​/b9-6+,17-12-/t18-/m1/s1
InCHI Key
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LDOCIRJMPUHXRM-YUJGFSRTSA-N

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15-deoxy-Δ12,14-Prostaglandin A1 is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $78.00 $0.00
1 mg $117.00 $0.00
5 mg $546.00 $0.00
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Pricing updated 2015-04-19. Prices are subject to change without notice.

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Related Products

15-deoxy-Δ12,14-Prostaglandin J2
15-keto Prostaglandin A1
Prostaglandin A1
Prostaglandin A1 methyl ester Exclusive
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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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