16,16-dimethyl Prostaglandin A1

Cayman Chemical Item Number 10080

16,16-dimethyl PGA1 (CAS 41692-24-4)

16,16-dimethyl Prostaglandin A1 (CAS 41692-24-4)

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Description

16,16-dimethyl PGA1 is a metabolism resistant analog of PGA1. In vitro, it inhibits the viral replication in both HSV and HIV-1 infection systems at concentrations that do not adversely alter cellular DNA synthesis. The ID50 for HSV-1 strains in Vero cells and human foreskin fibroblasts are 3.8-5.6 µg/ml and 4.6-7.3 µg/ml, respectively. The ID50 for T cells acutely infected with HIV-1 is 2.5 µg/ml.1

1 Hughes-Fulford, M., McGrath, M.S., Hanks, D., et al. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother 36 2253-2258 (1992).

Synonyms
  • 16,16-dimethyl PGA1
Formal Name 9-​oxo-​15R-​hydroxy-​16,​16-​dimethyl-​prosta-​10,​13E-​dien-​1-​oic acid
CAS Number 41692-24-4
Molecular Formula C22H36O4
Formula Weight 364.5
Formulation A solution in methyl acetate
Purity ≥98%
λmax 216 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC(C)​(C)​C(O)​\C=C\[C@H]​1C=CC(=O)​C1CCCCCCC(=O)​O
InCHI Code
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​1S/C22H36O4/c1-4-5-16-22(2,3)​20(24)​15-13-17-12-14-19(23)​18(17)​10-8-6-7-9-11-21(25)​26/h12-15,17-18,20,24H,4-11,16H2,1-3H3,(H,25,26)​/b15-13+/t17-,18-,20-/m1/s1
InCHI Key
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CTQQHQGBBMYJPT-DZFVFWAGSA-N

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16,16-dimethyl Prostaglandin A1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $70.00 $0.00
5 mg $315.00 $0.00
10 mg $560.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-17. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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