16,16-dimethyl Prostaglandin A1
Item № 10080
CAS № 41692-24-4
Purity ≥98%
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1 mg $70.00 $0.00
5 mg $315.00 $0.00
10 mg $560.00 $0.00

Pricing updated 2015-09-04. Prices are subject to change without notice.

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Description
Synonyms
  • 16,16-dimethyl PGA1

16,16-dimethyl PGA1 is a metabolism resistant analog of PGA1. In vitro, it inhibits the viral replication in both HSV and HIV-1 infection systems at concentrations that do not adversely alter cellular DNA synthesis. The ID50 for HSV-1 strains in Vero cells and human foreskin fibroblasts are 3.8-5.6 µg/ml and 4.6-7.3 µg/ml, respectively. The ID50 for T cells acutely infected with HIV-1 is 2.5 µg/ml.1

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View Screening Libraries with 16,16-dimethyl Prostaglandin A1
Technical Information
Formal Name 9-​oxo-​15R-​hydroxy-​16,​16-​dimethyl-​prosta-​10,​13E-​dien-​1-​oic acid
CAS Number 41692-24-4
Synonyms
  • 16,16-dimethyl PGA1
Molecular Formula C22H36O4
Formula Weight 364.5
Purity ≥98%
Formulation A solution in methyl acetate
λmax 216 nm
SMILES CCCCC(C)​(C)​C(O)​\C=C\[C@H]​1C=CC(=O)​C1CCCCCCC(=O)​O
InChI Code ​1S/C22H36O4/c1-4-5-16-22(2,3)​20(24)​15-13-17-12-14-19(23)​18(17)​10-8-6-7-9-11-21(25)​26/h12-15,17-18,20,24H,4-11,16H2,1-3H3,(H,25,26)​/b15-13+/t17-,18-,20-/m1/s1
InChI Key CTQQHQGBBMYJPT-DZFVFWAGSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 206 Kb PDF

Download Safety Data Sheet (SDS) 30 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Hughes-Fulford, M., McGrath, M.S., Hanks, D., et al. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother 36 2253-2258 (1992).

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