AL 8810 isopropyl ester (CAS 208114-93-6) (Inchi key NHXJEEIAJJWMNC-IHMKMYTQSA-N) || Cayman Chemical | Supplier
AL 8810 isopropyl ester
Item № 10113
CAS № 208114-93-6
Purity >98%
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1 mg $57.00 $0.00
5 mg $257.00 $0.00
10 mg $456.00 $0.00

Pricing updated 2015-09-01. Prices are subject to change without notice.

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Description

AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F (Item No. 16010) which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (Item No. 16812) and Travoprost.2,3 The pharmacology of AL 8810 isopropyl ester has not been published.

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Technical Information
Formal Name 9α,​15R-​dihydroxy-​11β-​fluoro-​15-​(2,​3-​dihydro-​1H-​inden-​2-​yl)-​16,​17,​18,​19,​20-​pentanor-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ isopropyl ester
CAS Number 208114-93-6
Molecular Formula C27H37FO4
Formula Weight 444.6
Purity >98%
Formulation A crystalline solid
SMILES CC(C)​OC(CCC/C=C\C[C@@H]​1[C@@H]​(/C=C/[C@H]​(O)​C2CC3=CC=CC=C3C2)​[C@@H]​(F)​C[C@@H]​1O)​=O
InChI Code ​1S/C27H37FO4/c1-18(2)​32-27(31)​12-6-4-3-5-11-23-22(24(28)​17-26(23)​30)​13-14-25(29)​21-15-19-9-7-8-10-20(19)​16-21/h3,5,7-10,13-14,18,21-26,29-30H,4,6,11-12,15-17H2,1-2H3/b5-3-,14-13+/t22-,23-,24+,25+,26+/m1/s1
InChI Key NHXJEEIAJJWMNC-IHMKMYTQSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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Download Product Insert 155 Kb PDF

Download Safety Data Sheet (SDS) 25 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F analog with selective antagonist effects at the prostaglandin F (FP) receptor. J Pharmacol Exp Ther 290(3) 1278-1284 (1999).

2. Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

3. Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

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