AL 8810 isopropyl ester

Cayman Chemical Item Number 10113

(CAS 208114-93-6)

AL 8810 isopropyl ester (CAS 208114-93-6)

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Description

AL 8810 is an 11β-fluoro analog of prostaglandin F (PGF) which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost2 and Travoprost.3 The pharmacology of AL 8810 isopropyl ester has not been published.

1 Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F analog with selective antagonist effects at the prostaglandin F (FP) receptor. J Pharmacol Exp Ther 290(3) 1278-1284 (1999).

2 Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

3 Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

Formal Name 9α,​15R-​dihydroxy-​11β-​fluoro-​15-​(2,​3-​dihydro-​1H-​inden-​2-​yl)-​16,​17,​18,​19,​20-​pentanor-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ isopropyl ester
CAS Number 208114-93-6
Molecular Formula C27H37FO4
Formula Weight 444.6
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(C)​OC(CCC/C=C\C[C@@H]​1[C@@H]​(/C=C/[C@H]​(O)​C2CC3=CC=CC=C3C2)​[C@@H]​(F)​C[C@@H]​1O)​=O
InCHI Code
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​1S/C27H37FO4/c1-18(2)​32-27(31)​12-6-4-3-5-11-23-22(24(28)​17-26(23)​30)​13-14-25(29)​21-15-19-9-7-8-10-20(19)​16-21/h3,5,7-10,13-14,18,21-26,29-30H,4,6,11-12,15-17H2,1-2H3/b5-3-,14-13+/t22-,23-,24+,25+,26+/m1/s1
InCHI Key
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NHXJEEIAJJWMNC-IHMKMYTQSA-N

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AL 8810 isopropyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $57.00 $0.00
5 mg $257.00 $0.00
10 mg $456.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-19. Prices are subject to change without notice.

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Related Products

AL 8810
AL 8810 ethyl amide
AL 8810 methyl ester
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Fluprostenol isopropyl ester
Latanoprost
Latanoprost (free acid)
Prostaglandin F
(S)-AL 8810
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