Item № 10137
CAS № 36945-98-9
Purity ≥98%
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5 mg $40.00 $0.00
10 mg $67.00 $0.00
50 mg $308.00 $0.00
100 mg $448.00 $0.00

Pricing updated 2015-11-26. Prices are subject to change without notice.

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  • AG 3-5

Nociceptive sensory peripheral neurons often express both heat sensitive (VR1) and cold-sensitive (CMR1 (rat); TRPM8 (human)) receptors that are part of the transient receptor potential (TRP) superfamily. Icilin (AG 3-5) is a synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent than the reference cold thermosensory agonist, l-menthol.1 Icilin induces sensations of intense cold when applied orally in humans, and induces 'wet dog shakes', a behavioral marker of cold sensation, when given to rats. Icilin should serve as the reference cold nociceptive agonist for TRP-type ion channels in the future.2

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Technical Information
Formal Name 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone
CAS Number 36945-98-9
  • AG 3-5
Molecular Formula C16H13N3O4
Formula Weight 311.3
Purity ≥98%
Formulation A crystalline solid
SMILES O=C1N([H])C(C2=CC([N+]([O-])=O)=CC=C2)=CCN1C3=CC=CC=C3O
InChI Code 1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. McKemy, D.D., Neuhausser, W.M., and Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52-58 (2002).

2. Wei, E.T., and Seid, D.A. AG-3-5: A chemical producing sensations of cold. J Pharm Pharmacol 35 110-112 (1983).

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