Histone H4 (human recombinant)

Cayman Chemical Item Number 10264

Histone H4; H4

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Peptide sequence: Amino acids 1-103 (full-length) · Source: recombinant protein expressed in E. coli · MW: 11.5 kDa · A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octomer of histones.1 The octamer is composed of two copies of each histone H2A, H2B, H3 and H4. Histones H2A and H2B each form homodimers. Histones H3 and H4 form a tetramer. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. 2 The N-terminal tail of histone H4 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1

1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 14(11) 1008-1016 (2007).

2. Tanaka, Y., Tawaramoto-Sasanuma, M., Kawaguchi, S., et al. Expression and purification of recombinant human histones. Methods 33 3-11 (2004).

  • Histone H4
  • H4
Formulation A lyophilized powder
Purity ≥95% estimated by SDS-PAGE
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

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Size Price Quantity Subtotal
1 mg $350.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Histone H4 Peptide Substrate (1-21)
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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


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