EUK 118

Cayman Chemical Item Number 10271

(CAS 186299-34-3)

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Description

EUK 8 and EUK 134 are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.1 EUK 118 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 118 exhibits a catalase activity of 35 µM O2 formed/minute from 10 mM hydrogen peroxide, which is more than four times lower that that observed for EUK 8 under the same conditions.2 Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 and EUK 8 with IC50 values of 2 and 0.7 µM, respectively. EUK 118 did not protect human dermal fibroblasts against hydrogen peroxide-induced cell death.2

1. Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

2. Doctrow, S.R., Huffman, K., Marcus, C.B., et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J Med Chem 45 4549-4558 (2002).

Formal Name (acetato-​κO)[[2,​2'-​[1,​2-​ethanediylbis[(nitrilo-​κN)methylidyne]]bis[3,​5-​dimethoxyphenolato-​κO]](2-​)]-​manganese
CAS Number 186299-34-3
Molecular Formula C22H25MnN2O8
Formula Weight 500.4
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC([O-]​[Mn]​123([N]​(CC[N]​2=CC4=C(OC)​C=C(OC)​C=C4[O-]​3)​=CC5=C(OC)​C=C(OC)​C=C5[O-]​1)​[Mn]​[Mn+]​)​=O
InCHI Code
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​1S/C20H24N2O6.C2H4O2.3Mn/c1-25-13-7-17(23)​15(19(9-13)​27-3)​11-21-5-6-22-12-16-18(24)​8-14(26-2)​10-20(16)​28-4;1-2(3)​4;;;/h7-12,23-24H,5-6H2,1-4H3;1H3,(H,3,4)​;;;/q;;;;+1/p-3/b21-11+,22-12+;;;;
InCHI Key
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OLFXCYRUBIJZQW-CAGONKBASA-K

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Size Price Quantity Subtotal
5 mg $25.00 $0.00
10 mg $48.00 $0.00
50 mg $200.00 $0.00
100 mg $350.00 $0.00
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Related Products

EUK 124
EUK 134
MCI-186

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Ann Arbor, Michigan 48108 USA

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