16,16-dimethyl Prostaglandin A2

Cayman Chemical Item Number 10280

16,16-dimethyl PGA2 (CAS 41691-92-3)

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16,16-dimethyl PGA2 is a metabolism-resistant analog of PGA2 with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 µg/ml.1 Daily infusion of 10 µg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%.2 Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.3

1. Santoro, M.G., Benedetto, A., Carruba, G., et al. Prostaglandin A compounds as antiviral agents. Science 209 1032-1034 (1980).

2. Santoro, M.G., Favalli, C., Mastino, A., et al. Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus.. Arch Virol 99 89-100 (1988).

3. Marini, S., Palamara, A.T., Garaci, E., et al. Growth inhibition of friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: An action independent of natural killer-activity. Br J Cancer 61 394-399 (1990).

  • 16,16-dimethyl PGA2
Formal Name 9-​oxo-​15R-​hydroxy-​16,​16-​dimethyl-​prosta-​5Z,​10,​13E-​trien-​1-​oic acid
CAS Number 41691-92-3
Molecular Formula C22H34O4
Formula Weight 362.5
Formulation A solution in methyl acetate
Purity >98%
λmax 215 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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16,16-dimethyl Prostaglandin A2 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $74.00 $0.00
5 mg $333.00 $0.00
10 mg $592.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

16,16-dimethyl Prostaglandin A1
Prostaglandin A2
Prostaglandin A2 methyl ester


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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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