16,16-dimethyl Prostaglandin A2

Cayman Chemical Item Number 10280

16,16-dimethyl PGA2 (CAS 41691-92-3)

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Description

16,16-dimethyl PGA2 is a metabolism-resistant analog of PGA2 with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 µg/ml.1 Daily infusion of 10 µg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%.2 Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.3

1. Santoro, M.G., Benedetto, A., Carruba, G., et al. Prostaglandin A compounds as antiviral agents. Science 209 1032-1034 (1980).

2. Santoro, M.G., Favalli, C., Mastino, A., et al. Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus.. Arch Virol 99 89-100 (1988).

3. Marini, S., Palamara, A.T., Garaci, E., et al. Growth inhibition of friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: An action independent of natural killer-activity. Br J Cancer 61 394-399 (1990).

Synonyms
  • 16,16-dimethyl PGA2
Formal Name 9-​oxo-​15R-​hydroxy-​16,​16-​dimethyl-​prosta-​5Z,​10,​13E-​trien-​1-​oic acid
CAS Number 41691-92-3
Molecular Formula C22H34O4
Formula Weight 362.5
Formulation A solution in methyl acetate
Purity >98%
λmax 215 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1[C@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​C(C)​(C)​CCCC)​C=C1
InCHI Code
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​1S/C22H34O4/c1-4-5-16-22(2,3)​20(24)​15-13-17-12-14-19(23)​18(17)​10-8-6-7-9-11-21(25)​26/h6,8,12-15,17-18,20,24H,4-5,7,9-11,16H2,1-3H3,(H,25,26)​/b8-6-,15-13+/t17-,18-,20-/m1/s1
InCHI Key
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MOTPSJUHMGPRFZ-QEJIITRLSA-N

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16,16-dimethyl Prostaglandin A2 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $74.00 $0.00
5 mg $333.00 $0.00
10 mg $592.00 $0.00
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Related Products

16,16-dimethyl Prostaglandin A1
Prostaglandin A2
Prostaglandin A2 methyl ester Exclusive

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