Griffithsin • GRFT || Cayman Chemical | Supplier
Griffithsin
Item № 10340
Purity ≥95%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
25 µg $92.00 $0.00
50 µg $175.00 $0.00
100 µg $330.00 $0.00

Pricing updated 2015-08-31. Prices are subject to change without notice.

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Description
Synonyms
  • GRFT

Griffithsin (GRFT), is a lectin isolated from Griffithsia sp. with anti-HIV activity at subnanomolar concentrations.1 GRFT activity is glycosylation-dependent and acts by binding to glycoproteins gp41, gp120, and gp160 on the viral envelope, blocking the virus from binding to CD4 receptor-expressing cells in the host. It also prevents cell fusion between infected and uninfected cells, further inhibiting the spread of HIV in the body. GRFT functions as a homodimer, with each monomer containing three carbohydrate binding sites.1,2 GRFT unique anti-viral activity is of interest for use in microbicide production to stop transmission of HIV through sexual contact. It has also been shown to have inhibitory effects with SARS-related coronavirus; where GRFT binding to the SARS-CoV S protein can prevent viral entry and reduce viral load in succeeding rounds of infection.3

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Technical Information
Synonyms
  • GRFT
Purity ≥95%
Source Recombinant N-terminal His-tagged GRFT, purified from E. coli
MW 14.6 kDa
Formulation 50 mM sodium phosphate pH 7.2, containing100 mM sodium chloride, 2.5 mM DTT, and 20% glycerol
UniProt Accession № P84801

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Stability 9 months
Product Downloads & Resources
Product Downloads

Download Product Insert 97 Kb PDF

Download Safety Data Sheet (SDS) 25 Kb PDF

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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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Inserts
QC Sheets
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GCMS Data
References & Background Reading
Product Description References

1. Mori, T., O'Keefe, B.R., Sowder, R.C., et al. Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.. J Biol Chem 280(10) 9345-9353 (2005).

2. Ziólkowska, N.E., O'Keefe, B.R., Mori, T., et al. Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure 14 1127-1135 (2006).

3. O'Keefe, B.R., Giomarelli, B., Barnard, D.L., et al. Broad spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol (2009).

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