Cayman Chemical Item Number 10398

(CAS 300801-52-9)

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Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively.1 TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 μM, respectively).1 Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro.1 At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.1

1. Muraki, M., Ohkawara, B., Hosoya, T., et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem 279(23) 24246-24254 (2004).

Formal Name 1-​(3-​ethyl-​5-​methoxy-​2(3H)-​benzothiazolylidene)-​2-​propanone
CAS Number 300801-52-9
Molecular Formula C13H15NO2S
Formula Weight 249.3
Formulation A crystalline solid
Purity ≥95%
λmax 215, 250, 362 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $18.00 $0.00
5 mg $81.00 $0.00
10 mg $144.00 $0.00
25 mg $315.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-27. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


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