TG003

Cayman Chemical Item Number 10398

(CAS 300801-52-9)

TG003 (CAS 300801-52-9)

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Description

Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively.1 TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 μM, respectively).1 Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro.1 At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.1

1 Muraki, M., Ohkawara, B., Hosoya, T., et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem 279(23) 24246-24254 (2004).

Formal Name 1-​(3-​ethyl-​5-​methoxy-​2(3H)-​benzothiazolylidene)-​2-​propanone
CAS Number 300801-52-9
Molecular Formula C13H15NO2S
Formula Weight 249.3
Formulation A crystalline solid
Purity ≥95%
λmax 215, 250, 362 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCN(C1=CC(OC)​=CC=C1S/2)​C2=C\C(C)​=O
InCHI Code
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​1S/C13H15NO2S/c1-4-14-11-8-10(16-3)​5-6-12(11)​17-13(14)​7-9(2)​15/h5-8H,4H2,1-3H3/b13-7-
InCHI Key
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BGVLELSCIHASRV-QPEQYQDCSA-N

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TG003 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $18.00 $0.00
5 mg $81.00 $0.00
10 mg $144.00 $0.00
25 mg $315.00 $0.00
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Pricing updated 2014-04-17. Prices are subject to change without notice.

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