Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain.1,2,3 Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration.4,5 CAY10632 is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina.4,6
1Aveldaño, M.I.Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes. Biochemistry271229-1239(1988).
2Robinson, B.S., Johnson, D.W., and Poulos, A.Novel molecular species of spingomyelin containing 2-hydroxylated polyenoic very-long-chain fatty acids in mammalian testes and spermatozoa. J Biol Chem2671746-1751(1992).
3Robinson, B.S., Johnson, D.W., and Poulos, A.Unique molecular species of phophatidylcholine containing very-long-chain (C24-C38) polyenoic fatty acids in rat brain. Biochem J265763-7(1990).
4McMahon, A., Jackson, S.N., Woods, A.S., et al. A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C32-C36 acyl phosphatidylcholines. FEBS Lett5815459-5463(2007).
5Agbaga, M., Mandal, M.N.A., and Anderson, R.E.Retinal very long-chain PUFAs: New insights from studies on ELOVL4 protein. J Lipid Res511624-1642(2010).
6Agbada, M., Brush, R.S., Mandal, N.A., et al. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc Natl Acad Sci USA105(35)12843-8(2008).
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.
Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research
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