BayCysLT2 Exclusive

Cayman Chemical Item Number 10532

CAY10633 (CAS 712313-33-2)

BayCysLT2 (CAS 712313-33-2)

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Description

The cysteinyl leukotrienes LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G-protein coupled receptors, CysLT1 and CysLT2.1,2,3 BayCysLT2 is a potent CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 35 and >10,000 nM, respectively.4 BayCysLT2 concentration-dependently reverses LTC4-stimulated perfusion pressure increase and contractility decrease in isolated Langendorff-perfused guinea pig hearts.4

1 Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 789-793 (1999).

2 Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 275 30531-30536 (2000).

3 Sarau, H.M., Ames, R.S., Chambers, J., et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol 56 657-663 (1999).

4 Harter, M., Erguden, J., Wunder, F., et al. Isophtalic acid derivatives. 10/537,623 1-104 (2006 Jul 13).

Synonyms
  • CAY10633
Formal Name 3-​[[(3-​carboxycyclohexyl)amino]carbonyl]-​4-​[3-​[4-​(4-​phenoxybutoxy)phenyl]propoxy]-​benzoic acid
CAS Number 712313-33-2
Molecular Formula C34H39NO8
Formula Weight 589.7
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(NC1CCCC(C(O)​=O)​C1)​C2=CC(C(O)​=O)​=CC=C2OCCCC(C=C3)​=CC=C3OCCCCOC4=CC=CC=C4
InCHI Code
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​1S/C34H39NO8/c36-32(35-27-10-6-9-25(22-27)​33(37)​38)​30-23-26(34(39)​40)​15-18-31(30)​43-21-7-8-24-13-16-29(17-14-24)​42-20-5-4-19-41-28-11-2-1-3-12-28/h1-3,11-18,23,25,27H,4-10,19-22H2,(H,35,36)​(H,37,38)​(H,39,40)​
InCHI Key
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GKPAULTWHHPIHX-UHFFFAOYSA-N

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Size Price Quantity Subtotal
1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00
25 mg $753.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2014-04-20. Prices are subject to change without notice.

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