4-pentynoyl-Coenzyme A (trifluoroacetate salt) Exclusive

Cayman Chemical Item Number 10547

Click Tag™ 4-pentynoyl-CoA

4-pentynoyl-Coenzyme A (trifluoroacetate salt)

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Description

Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that enables rapid detection of acetylated proteins both in vivo and in vitro.1 As an acyl-CoA donor, the 4-pentynoyl analog is metabolically transferred onto lysine residues of proteins by lysine acetyltransferases. An azide-alkyne bioconjugation reaction, known as ‘click chemistry’, can then be used to readily tag acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.2

1 Yang, Y., Ascano, J.M., and Hang, H.C. Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc 132 3640-3641 (2010).

2 Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discov Today 8(24) 1128-1137 (2003).

Synonyms
  • Click Tag™ 4-pentynoyl-CoA
Formal Name S-​4-​pentynoate coenzyme A,​ trifluoroacetate salt
Molecular Formula C26H40N7O17P3S • CF3COOH
Formula Weight 961.6
Formulation A lyophilized powder
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(C(F)​(F)​F)​=O.NC1=NC=NC2=C1N=CN2[C@@]​3([H]​)​[C@@]​(O)​([H]​)​[C@@]​(OP(O)​(O)​=O)​([H]​)​[C@]​(COP(OP(OCC(C)​(C)​[C@@H]​(O)​C(NCCC(NCCSC(CCC#C)​=O)​=O)​=O)​(O)​=O)​(O)​=O)​([H]​)​O3
InCHI Code
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​1S/C26H40N7O17P3S.C2HF3O2/c1-4-5-6-17(35)​54-10-9-28-16(34)​7-8-29-24(38)​21(37)​26(2,3)​12-47-53(44,45)​50-52(42,43)​46-11-15-20(49-51(39,40)​41)​19(36)​25(48-15)​33-14-32-18-22(27)​30-13-31-23(18)​33;3-2(4,5)​1(6)​7/h1,13-15,19-21,25,36-37H,5-12H2,2-3H3,(H,
InCHI Key
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SIDLSNSJGSPOJG-WADKRTIVSA-N

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Size Price Quantity Subtotal
500 µg $60.00 $0.00
1 mg $114.00 $0.00
5 mg $480.00 $0.00
10 mg $840.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-24. Prices are subject to change without notice.

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