4-pentynoyl-Coenzyme A (trifluoroacetate salt)

Cayman Chemical Item Number 10547

Click Tag™ 4-pentynoyl-CoA

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Description

Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that enables rapid detection of acetylated proteins both in vivo and in vitro.1 As an acyl-CoA donor, the 4-pentynoyl analog is metabolically transferred onto lysine residues of proteins by lysine acetyltransferases. An azide-alkyne bioconjugation reaction, known as click chemistry, can then be used to readily tag acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.2

1. Yang, Y., Ascano, J.M., and Hang, H.C. Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc 132 3640-3641 (2010).

2. Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discov Today 8(24) 1128-1137 (2003).

Synonyms
  • Click Tag™ 4-pentynoyl-CoA
Formal Name S-​4-​pentynoate coenzyme A,​ trifluoroacetate salt
Molecular Formula C26H40N7O17P3S • CF3COOH
Formula Weight 961.6
Formulation A lyophilized powder
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(C(F)​(F)​F)​=O.NC1=NC=NC2=C1N=CN2[C@@]​3([H]​)​[C@@]​(O)​([H]​)​[C@@]​(OP(O)​(O)​=O)​([H]​)​[C@]​(COP(OP(OCC(C)​(C)​[C@@H]​(O)​C(NCCC(NCCSC(CCC#C)​=O)​=O)​=O)​(O)​=O)​(O)​=O)​([H]​)​O3
InCHI Code
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​1S/C26H40N7O17P3S.C2HF3O2/c1-4-5-6-17(35)​54-10-9-28-16(34)​7-8-29-24(38)​21(37)​26(2,3)​12-47-53(44,45)​50-52(42,43)​46-11-15-20(49-51(39,40)​41)​19(36)​25(48-15)​33-14-32-18-22(27)​30-13-31-23(18)​33;3-2(4,5)​1(6)​7/h1,13-15,19-21,25,36-37H,5-12H2,2-3H3,(H,
InCHI Key
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SIDLSNSJGSPOJG-WADKRTIVSA-N

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Size Price Quantity Subtotal
500 µg $60.00 $0.00
1 mg $114.00 $0.00
5 mg $480.00 $0.00
10 mg $840.00 $0.00
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Pricing updated 2015-05-22. Prices are subject to change without notice.

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Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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