C-16 Ceramide

Cayman Chemical Item Number 10681

Palmitoyl Ceramide (CAS 24696-26-2)

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Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway, which requires coordinate action of serine palmitoyl transferase and ceramide synthase. They have been shown to mediate antiproliferative responses such as apoptosis, growth arrest, differentiation, and senescence.1 C-16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts a lipid second messenger to regulate apoptosis and stress signaling.2 Accumulation of C-16 ceramide through PPMP (30 μM) or MAPP (50 μM) treatment or from addition of 100 μM synthetic C-16 ceramide induces apoptosis in neutrophil cultures via caspase-3 activation.3

1. Ogretmen, B., Pettus, B.J., Rossi, M.J., et al. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A547 human lung adenocarcinoma cell line. J Biol Chem 277(15) 12960-9 (2002).

2. White-Gilbertson, S., Mullen, T., Senkal, C., et al. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells. Oncogene 28(8) 1132-1141 (2009).

3. Seumois, G., Fillet, M., Gillet, L., et al. De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. J Leukoc Biol 81 1477-86 (2007).

  • Palmitoyl Ceramide
Formal Name N-​[2R-​hydroxy-​1S-​(hydroxymethyl)-​3E-​heptadecen-​1-​yl]-​hexadecanamide
CAS Number 24696-26-2
Molecular Formula C34H67NO3
Formula Weight 537.9
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $10.00 $0.00
5 mg $45.00 $0.00
10 mg $80.00 $0.00
25 mg $175.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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