C-20 Ceramide
Item № 10724
CAS № 7344-02-7
Purity ≥98%
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1 mg $10.00 $0.00
5 mg $45.00 $0.00
10 mg $80.00 $0.00
25 mg $175.00 $0.00

Pricing updated 2016-02-06. Prices are subject to change without notice.

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Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway. Certain forms of ceramide have been shown to mediate cellular responses such as apoptosis, growth arrest, and differentiation in certain cell types.1,2 C-20 Ceramide is a natural 20:0 ceramide that is abundant in the brain. It is synthesized de novo by ceramide synthases 1 and 2.3,4

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Technical Information
Formal Name N-[2R-hydroxy-1S-(hydroxymethyl)-3E-heptadecen-1-yl]-eicosanamide
CAS Number 7344-02-7
Molecular Formula C38H75NO3
Formula Weight 594.0
Purity ≥98%
Formulation A crystalline solid
InChI Code 1S/C38H75NO3/c1-3-5-7-9-11-13-15-17-18-19-20-22-24-26-28-30-32-34-38(42)39-36(35-40)37(41)33-31-29-27-25-23-21-16-14-12-10-8-6-4-2/h31,33,36-37,40-41H,3-30,32,34-35H2,1-2H3,(H,39,42)/b33-31+/t36-,37+/m0/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Ogretmen, B., Pettus, B.J., Rossi, M.J., et al. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A547 human lung adenocarcinoma cell line. J Biol Chem 277(15) 12960-9 (2002).

2. Pandey, S., Murphy, R.F., and Agrawal, D.K. Recent advances in the immunobiology of ceramide. Exp Mol Pathol 82(3) 298-309 (2007).

3. Cowart, L.A. Sphingolipids: Players in the pathology of metabolic disease. Trends Endocrinol Metab 20(1) 34-42 (2008).

4. Pewzner-Jung, Y., Ben-Dor, S., and Futerman, A.H. When do lasses (longevity assurance genes) become CerS (ceramide synthases)? J Biol Chem 281(35) 25001-5 (2006).

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