Clofibrate

Cayman Chemical Item Number 10956

(CAS 637-07-0)

Clofibrate (CAS 637-07-0)

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Description

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.3 Clofibrate is a PPARα agonist and a member of a class of hypolipidemic drugs that includes fenofibrate and benzafibrate, which have been used clinically to treat dyslipidemia and cardiovascular disease. In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for mouse and human PPARα, respectively.4 It also binds to PPARγ, but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM.4

1 Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

2 Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

3 Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci 61 393-416 (2004).

4 Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

Formal Name 2-​(4-​chlorophenoxy)-​2-​methyl-​propanoic acid,​ ethyl ester
CAS Number 637-07-0
Molecular Formula C12H15ClO3
Formula Weight 242.7
Formulation A colorless liquid
Purity ≥98%
λmax 226, 279 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCOC(=O)​C(C)​(C)​Oc1ccc(Cl)​cc1
InCHI Code
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​1S/C13H15ClO4/c1-4-17-12(16)​11(15)​13(2,3)​18-10-7-5-9(14)​6-8-10/h5-8H,4H2,1-3H3
InCHI Key
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VARQCTQXIPMTCK-UHFFFAOYSA-N

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Size Price Quantity Subtotal
500 mg $13.00 $0.00
1 g $25.00 $0.00
5 g $104.00 $0.00
10 g $182.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-19. Prices are subject to change without notice.

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