AM2233

Cayman Chemical Item Number 11008

(CAS 444912-75-8)

AM2233 (CAS 444912-75-8)

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Description

AM2233 is a full agonist of the central cannabinoid (CB1) receptor (Ki = 2.8 nM).1 Most of the affinity towards the CB1 receptor resides within the (R)-enantiomer of AM2233, which exhibits a Ki value of 0.2 nM and has ~8-fold higher affinity for CB1 compared to WIN 55,212-2 (Ki = 1.6 nM).1 AM2233 was developed for use as a selective radioligand for mapping the distribution of the CB1 receptor in the brain.1 Recently, however, AM2233 has received attention as a cannabimimetic acquired for recreational use as a “legal high” replacement for restricted substances. This compound is intended for forensic and research applications.

1 Deng, H., Gifford, A.N., Zvonok, A.M., et al. Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor. J Med Chem 48 6386-6392 (2005).

Formal Name (2-​iodophenyl)[1-​[(1-​methyl-​2-​piperidinyl)methyl]-​1H-​indol-​3-​yl]-​methanone
CAS Number 444912-75-8
Molecular Formula C22H23IN2O
Formula Weight 458.3
Formulation A crystalline solid
Purity ≥98%
λmax 213, 250, 314 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C(C1=C(I)​C=CC=C1)​C2=CN(CC3N(C)​CCCC3)​C4=CC=CC=C42
InCHI Code
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​1S/C22H23IN2O/c1-24-13-7-6-8-16(24)​14-25-15-19(17-9-3-5-12-21(17)​25)​22(26)​18-10-2-4-11-20(18)​23/h2-5,9-12,15-16H,6-8,13-14H2,1H3
InCHI Key
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KSLCYQTUSSEGPT-UHFFFAOYSA-N

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Size Price Quantity Subtotal
1 mg $25.00 $0.00
5 mg $65.00 $0.00
10 mg $139.00 $0.00
25 mg $260.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-19. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

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