Core Histones (human)

Cayman Chemical Item Number 11010

HeLa Core Histones

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Description

Source: Highly purified mixture of human core histones (H2A, H2B, H3, and H4) isolated via hydroxyapatite chromatography from HeLa S3 (human cervical adenocarcinoma) nuclear pelle · A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4.1 The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core.2 Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1

1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 14(11) 1008-1016 (2007).

2. Tanaka, Y., Tawaramoto-Sasanuma, M., Kawaguchi, S., et al. Expression and purification of recombinant human histones. Methods 33 3-11 (2004).

Synonyms
  • HeLa Core Histones
Formulation 50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-mercaptoethanol
Purity ≥95%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

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Size Price Quantity Subtotal
100 µg $259.00 $0.00
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Pricing updated 2015-04-25. Prices are subject to change without notice.

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