Pricing updated 2015-08-29. Prices are subject to change without notice.
A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4.1 The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core.2 Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1
|Source||Highly purified mixture of human core histones (H2A, H2B, H3, and H4) isolated via hydroxyapatite chromatography from HeLa S3 (human cervical adenocarcinoma) nuclear pelle|
|Formulation|| 50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-
WARNING - This product is not for human or veterinary use.
|Shipping||Dry ice in continental US; may vary elsewhere|
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1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 14(11) 1008-1016 (2007).
Tanaka, Y., Tawaramoto-
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