DL-Palmitoylcarnitine (chloride)

Cayman Chemical Item Number 11095

Palmitoyl-DL-carnitine chloride; NSC 628323 (CAS 6865-14-1)

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DL-Palmitoylcarnitine (chloride) is a long-chain acylcarnitine with both intracellular and extracellular roles. Within the cell, palmitoylcarnitine is transported into mitochondria to deliver palmitate for fatty acid oxidation and energy production.1 Exogenously added DL-palmitoylcarnitine alters calcium mobilization in many cell types.2,3,4 It also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability while decreasing cell viability.5,6

1. Bezaire, V., Bruce, C.R., Heigenhauser, G.J.F., et al. Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: Essential role in fatty acid oxidation. Am J Physiol Endocrinol Metab 290(3) E509-E515 (2006).

2. El-Hayek, R., Valdivia, C., Valdivia, H.H., et al. Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. Biophys J 65(2) 779-789 (1993).

3. Stapleton, S.R., Currie, K.P.M., Scott, R.H., et al. Palmitoyl-DL-carnitine has calcium-dependent effects on cultured neurones from rat dorsal root ganglia. Br J Pharmacol 107 1192-1197 (1992).

4. Muraki, K., and Imaizumi, Y. A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. J Pharmacol Sci 92 252-258 (2003).

5. Duizer, E., van der Wulp, C., Versantvoort, C.H.M., et al. Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells. J Pharmacol Exp Ther 287(1) 395-402 (1998).

6. Ma, L., Kuang, K., Smith, R.W., et al. Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium. Exp Eye Res 84(4) 790-798 (2007).

  • Palmitoyl-DL-carnitine chloride
  • NSC 628323
Formal Name 3-​carboxy-​N,​N,​N-​trimethyl-​2-​[(1-​oxohexadecyl)oxy]-​1-​propanaminium,​ chloride
CAS Number 6865-14-1
Molecular Formula C23H46ClNO4
Formula Weight 436.1
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
50 mg $39.00 $0.00
100 mg $59.00 $0.00
500 mg $275.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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