DL-Palmitoylcarnitine (chloride)
Item № 11095
CAS № 6865-14-1
Purity ≥95%
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50 mg $39.00 $0.00
100 mg $59.00 $0.00
500 mg $275.00 $0.00

Pricing updated 2015-11-27. Prices are subject to change without notice.

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  • Palmitoyl-DL-carnitine chloride
  • NSC 628323

DL-Palmitoylcarnitine (chloride) is a long-chain acylcarnitine with both intracellular and extracellular roles. Within the cell, palmitoylcarnitine is transported into mitochondria to deliver palmitate for fatty acid oxidation and energy production.1 Exogenously added DL-palmitoylcarnitine alters calcium mobilization in many cell types.2,3,4 It also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability while decreasing cell viability.5,6

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Technical Information
Formal Name 3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium, chloride
CAS Number 6865-14-1
  • Palmitoyl-DL-carnitine chloride
  • NSC 628323
Molecular Formula C23H46ClNO4
Formula Weight 436.1
Purity ≥95%
Formulation A crystalline solid
InChI Code 1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Bezaire, V., Bruce, C.R., Heigenhauser, G.J.F., et al. Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: Essential role in fatty acid oxidation. Am J Physiol Endocrinol Metab 290(3) E509-E515 (2006).

2. El-Hayek, R., Valdivia, C., Valdivia, H.H., et al. Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. Biophys J 65(2) 779-789 (1993).

3. Stapleton, S.R., Currie, K.P.M., Scott, R.H., et al. Palmitoyl-DL-carnitine has calcium-dependent effects on cultured neurones from rat dorsal root ganglia. Br J Pharmacol 107 1192-1197 (1992).

4. Muraki, K., and Imaizumi, Y. A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. J Pharmacol Sci 92 252-258 (2003).

5. Duizer, E., van der Wulp, C., Versantvoort, C.H.M., et al. Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells. J Pharmacol Exp Ther 287(1) 395-402 (1998).

6. Ma, L., Kuang, K., Smith, R.W., et al. Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium. Exp Eye Res 84(4) 790-798 (2007).

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