NKH477 (hydrochloride)
Item № 11214
CAS № 138605-00-2
Purity ≥95%
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1 mg $19.00 $0.00
5 mg $76.00 $0.00
10 mg $114.00 $0.00

Pricing updated 2015-09-03. Prices are subject to change without notice.

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Description
Synonyms
  • Adehl
  • Colforsin Dapropate
  • ​Colforsin Daropate

Forskolin (Item No. 11018) is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously.1,2,3 Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases.1 This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms.4 NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.3

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Technical Information
Formal Name (3R,​4aR,​5S,​6S,​6aS,​10S,​10aR,​10bS)-​5-​(acetyloxy)-​3-​ethenyldodecahydro-​10,​10b-​dihydroxy-​3,​4a,​7,​7,​10a-​pentamethyl-​1-​β-​alanine,​ N,​N-​dimethyl-​oxo-​1H-​naphtho[2,​1-​b]pyran-​6-​yl ester,​ monohydrochloride
CAS Number 138605-00-2
Synonyms
  • Adehl
  • Colforsin Dapropate
  • ​Colforsin Daropate
Molecular Formula C27H43NO8 • HCl
Formula Weight 546.1
Purity ≥95%
Formulation A crystalline solid
SMILES O=C1C[C@@]​(C=C)​(C)​O[C@]​2(C)​[C@@H]​(OC(C)​=O)​[C@@H]​(OC(CCN(C)​C)​=O)​[C@@]​3([H]​)​C(C)​(C)​CC[C@H]​(O)​[C@]​3(C)​[C@]​21O.Cl
InChI Code ​1S/C27H43NO8.ClH/c1-10-24(5)​15-18(31)​27(33)​25(6)​17(30)​11-13-23(3,4)​21(25)​20(35-19(32)​12-14-28(8)​9)​22(34-16(2)​29)​26(27,7)​36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InChI Key VIRRLEDAYYYTOD-YHEOSNBFSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 110 Kb PDF

Download Safety Data Sheet (SDS) 29 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Hosono, M., Takahira, T., Fujita, A., et al. Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative. J Cardiovasc Pharmacol 19 625-634 (1992).

2. Sanbe, A., and Takeo, S. Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction. J Pharmacol Exp Ther 274 120-126 (1995).

3. Satake, K., Takagi, K., Kodama, I., et al. Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: The role of Ca2+-activated K+ channels. Br J Pharmacol 123 753-761 (1998).

4. Toya, Y., Schwencke, C., and Ishikawa, Y. Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. J Mol Cell Cardiol 30 97-108 (1998).

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