NKH477 (hydrochloride)

Cayman Chemical Item Number 11214

Adehl; Colforsin Dapropate; ​Colforsin Daropate (CAS 138605-00-2)

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Description

Forskolin (Item No. 11018) is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously.1,2,3 Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases.1 This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms.4 NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.3

1. Hosono, M., Takahira, T., Fujita, A., et al. Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative. J Cardiovasc Pharmacol 19 625-634 (1992).

2. Sanbe, A., and Takeo, S. Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction. J Pharmacol Exp Ther 274 120-126 (1995).

3. Satake, K., Takagi, K., Kodama, I., et al. Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: The role of Ca2+-activated K+ channels. Br J Pharmacol 123 753-761 (1998).

4. Toya, Y., Schwencke, C., and Ishikawa, Y. Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. J Mol Cell Cardiol 30 97-108 (1998).

Synonyms
  • Adehl
  • Colforsin Dapropate
  • ​Colforsin Daropate
Formal Name (3R,​4aR,​5S,​6S,​6aS,​10S,​10aR,​10bS)-​5-​(acetyloxy)-​3-​ethenyldodecahydro-​10,​10b-​dihydroxy-​3,​4a,​7,​7,​10a-​pentamethyl-​1-​β-​alanine,​ N,​N-​dimethyl-​oxo-​1H-​naphtho[2,​1-​b]pyran-​6-​yl ester,​ monohydrochloride
CAS Number 138605-00-2
Molecular Formula C27H43NO8 • HCl
Formula Weight 546.1
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1C[C@@]​(C=C)​(C)​O[C@]​2(C)​[C@@H]​(OC(C)​=O)​[C@@H]​(OC(CCN(C)​C)​=O)​[C@@]​3([H]​)​C(C)​(C)​CC[C@H]​(O)​[C@]​3(C)​[C@]​21O.Cl
InCHI Code
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​1S/C27H43NO8.ClH/c1-10-24(5)​15-18(31)​27(33)​25(6)​17(30)​11-13-23(3,4)​21(25)​20(35-19(32)​12-14-28(8)​9)​22(34-16(2)​29)​26(27,7)​36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InCHI Key
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VIRRLEDAYYYTOD-YHEOSNBFSA-N

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Size Price Quantity Subtotal
1 mg $19.00 $0.00
5 mg $76.00 $0.00
10 mg $114.00 $0.00
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Forskolin

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