Cyclopiazonic Acid

Cayman Chemical Item Number 11326

NSC 117181 (CAS 18172-33-3)

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Cyclopiazonic acid is a mycotoxin produced by molds including certain species of Penicillium and Aspergillus. Its toxicity is linked to its ability to specifically and reversibly inhibit sarco-endoplasmic reticulum Ca2+-ATPases (SERCA; IC50 = 0.6 μM).1,2 Cyclopiazonic acid does not inhibit a wide variety of other types of membrane-bound ATPases. It effectively inhibits SERCA in intact tissue, in smooth muscle and endothelium, as well as in isolated cells.3,4

1. Seidler, N.W., Jona, I., Vegh, M., et al. Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. J Biol Chem 264(30) 17816-17823 (1989).

2. Uyama, Y., Imaizumi, Y., and Watanabe, M. Effects of cyclopiazonic acid, a novel Ca2+-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle. Br J Pharmacol 106 208-214 (1992).

3. Mumtaz, S., Burdyga, G., Borisova, L., et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium 49(1-4) 66-77 (2011).

4. Berra-Romani, R., Raqeeb, A., Torres-Jácome, J., et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. J Vasc Res 49 65-76 (2012).

  • NSC 117181
Formal Name 10-​acetyl-​2,​6,​6aR,​7,​11aS,​11bR-​hexahydro-​11-​hydroxy-​7,​7-​dimethyl-​9H-​pyrrolo[1',​2':2,​3]isoindolo[4,​5,​6-​cd]indol-​9-​one
CAS Number 18172-33-3
Molecular Formula C20H20N2O3
Formula Weight 336.4
Formulation A crystalline solid
Purity ≥95%
λmax 224, 281 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $18.00 $0.00
5 mg $54.00 $0.00
10 mg $96.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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