11-deoxy-11-methylene Prostaglandin D2 • 11-<wbr/>deoxy-<wbr/>11-<wbr/>methylene PGD<sub>2</sub> (CAS 100648-29-1) (Inchi key ROZAFJXVUNORLT-SFIVEXQWSA-N) || Cayman Chemical | Supplier
11-deoxy-11-methylene Prostaglandin D2
Item № 12410
CAS № 100648-29-1
Purity >98%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
1 mg $57.00 $0.00
5 mg $257.00 $0.00
10 mg $456.00 $0.00

Pricing updated 2015-08-30. Prices are subject to change without notice.

Bulk Inquiry Form

X

Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

Description
Synonyms
  • 11-deoxy-11-methylene PGD2

Prostaglandin D2 (PGD2; Item No. 12010) is one of the five primary enzymatic prostaglandins derived directly from PGH2 (Item No. 17020). PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase.1 PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin.2 However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay.3 The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported.

Download Product Insert Download Safety Data Sheet (SDS)

Related Products

Show all 5 Hide all but first 3

View Related Product Categories
View Screening Libraries with 11-deoxy-11-methylene Prostaglandin D2
Technical Information
Formal Name 9α,​15S-​dihydroxy-​11-​methylene-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 100648-29-1
Synonyms
  • 11-deoxy-11-methylene PGD2
Molecular Formula C21H34O4
Formula Weight 350.5
Purity >98%
Formulation A solution in methyl acetate
SMILES CCCCCC(O)​/C=C/[C@H]​1C(=C)​CC(O)​C1C/C=C\CCCC(=O)​O
InChI Code ​1S/C21H34O4/c1-3-4-7-10-17(22)​13-14-18-16(2)​15-20(23)​19(18)​11-8-5-6-9-12-21(24)​25/h5,8,13-14,17-20,22-23H,2-4,6-7,9-12,15H2,1H3,(H,24,25)​/b8-5-,14-13+/t17-,18-,19+,20-/m0/s1
InChI Key ROZAFJXVUNORLT-SFIVEXQWSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
Product Downloads

Download Product Insert 211 Kb PDF

Download Safety Data Sheet (SDS) 31 Kb PDF

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

Inserts
QC Sheets
Certificates of Analysis
GCMS Data
References & Background Reading
Product Description References

1. Urade, Y., and Hayaishi, O. Prostaglandin D synthase: Structure and function. Vitam Horm 58 89-120 (2000).

2. Borten, M., DiLeo, L.A., and Friedman, E.A. Low-dose prostaglandin E2 analogue for cervical dilations prior to pregnancy termination. Am J Obstet Gynecol 150 561-565 (1984).

3. Torisawa, Y., Yamaguchi, T., Sakata, S., et al. Synthesis of 11-deoxo-11-methylene-prostaglandin D2 and its derivatives. Chem Pharm Bull 33(10) 4625-4628 (1985).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...