EUK 124

Cayman Chemical Item Number 12500

(CAS 186299-35-4)

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Description

EUK 8 and EUK 134 are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.1 EUK 124 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 124 and EUK 8 inhibit superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with IC50 values of 5 µM and 0.7 µM, respectively.2

1. Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

2. Doctrow, S.R., Huffman, K., Marcus, C.B., et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J Med Chem 45 4549-4558 (2002).

Formal Name chloro[[2,​2’-​[1,​2-​ethanediylbis[(nitrilo-​κN)methylidyne]]bis[3,​5-​dimethoxyphenolato-​κO]](2-​)]-​manganese
CAS Number 186299-35-4
Molecular Formula C20H22ClMnN2O6
Formula Weight 476.8
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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[Cl-]​[Mn+3]​123[N]​(CC[N]​2=CC4=C(OC)​C=C(OC)​C=C4[O-]​3)​=CC5=C(OC)​C=C(OC)​C=C5[O-]​1
InCHI Code
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​1S/C20H24N2O6.ClH.Mn/c1-25-13-7-17(23)​15(19(9-13)​27-3)​11-21-5-6-22-12-16-18(24)​8-14(26-2)​10-20(16)​28-4;;/h7-12,23-24H,5-6H2,1-4H3;1H;/q;;+3/p-3/b21-11+,22-12+;;
InCHI Key
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CZWTULNLOQLTRE-AIMLMLFYSA-K

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EUK 124 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $25.00 $0.00
10 mg $48.00 $0.00
50 mg $200.00 $0.00
100 mg $350.00 $0.00
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Pricing updated 2015-05-24. Prices are subject to change without notice.

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Related Products

EUK 118
EUK 134
MCI-186

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1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

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