Item № 13013
CAS № 856925-71-8
Purity ≥98%
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1 mg $29.00 $0.00
5 mg $123.00 $0.00
10 mg $232.00 $0.00
25 mg $508.00 $0.00

Pricing updated 2015-11-28. Prices are subject to change without notice.

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  • (S)-Blebbistatin

(−)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.1,2 It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).3 Through these effects, blebbistatin blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells. Blebbistatin is inactivated by UV light,4 which may be particularly important in fluorescent cell imaging applications.

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Technical Information
Formal Name 1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one
CAS Number 856925-71-8
  • (S)-Blebbistatin
Molecular Formula C18H16N2O2
Formula Weight 292.3
Purity ≥98%
Formulation A crystalline solid
λmax 236, 270, 298, 418 nm
SMILES CC1=CC2C(C=C1)N=C1N(CC[C@@]1(O)C2=O)c1ccccc1
InChI Code 1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Straight, A.F., Cheung, A., Limouze, J., et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743-1747 (2003).

2. Kovács, M., Tóth, J., Hetényi, C., et al. Mechanism of blebbistatin inhibition of myosin II. J Biol Chem 279(34) 35557-35563 (2004).

3. Limouze, J., Straight, A.F., Mitchison, T., et al. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil 25 337-341 (2004).

4. Kolega, J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem Biophys Res Commun 320 1020-1025 (2004).

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