Cayman Chemical Item Number 13013

(S)-Blebbistatin (CAS 856925-71-8)

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(−)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.1,2 It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).3 Through these effects, blebbistatin blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells. Blebbistatin is inactivated by UV light,4 which may be particularly important in fluorescent cell imaging applications.

1. Straight, A.F., Cheung, A., Limouze, J., et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743-1747 (2003).

2. Kovács, M., Tóth, J., Hetényi, C., et al. Mechanism of blebbistatin inhibition of myosin II. J Biol Chem 279(34) 35557-35563 (2004).

3. Limouze, J., Straight, A.F., Mitchison, T., et al. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil 25 337-341 (2004).

4. Kolega, J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem Biophys Res Commun 320 1020-1025 (2004).

  • (S)-Blebbistatin
Formal Name 1,​2,​3,​3a-​tetrahydro-​3aS-​hydroxy-​6-​methyl-​1-​phenyl-​4H-​Pyrrolo[2,​3-​b]quinolin-​4-​one
CAS Number 856925-71-8
Molecular Formula C18H16N2O2
Formula Weight 292.3
Formulation A crystalline solid
Purity ≥98%
λmax 236, 270, 298, 418 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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(−)-Blebbistatin is available in the following screening library:

Size Price Quantity Subtotal
1 mg $29.00 $0.00
5 mg $123.00 $0.00
10 mg $232.00 $0.00
25 mg $508.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-30. Prices are subject to change without notice.

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