1a,1b-dihomo Prostaglandin E1

Cayman Chemical Item Number 13050

1a,1b-dihomo PGE1 (CAS 23452-98-4)

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Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.1,2 COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.3 In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.4

1. Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

2. Hoshi, K. Approved indications of lipo-PGE1 in Japan. Adv Drug Deliv Rev 20 171-176 (1996).

3. Samel, N., and Maxey, K.M. Personal Communication. (2003).

4. Kloeze, J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys Acta 187 285-292 (1969).

  • 1a,1b-dihomo PGE1
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​1a,​1b-​dihomo-​prost-​13E-​en-​1-​oic acid
CAS Number 23452-98-4
Molecular Formula C22H38O5
Formula Weight 382.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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1a,1b-dihomo Prostaglandin E1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Adrenic Acid
Prostaglandin A1 methyl ester
Prostaglandin E1


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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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