1a,1b-dihomo Prostaglandin E1

Cayman Chemical Item Number 13050

1a,1b-dihomo PGE1

1a,1b-dihomo Prostaglandin E1

See more

Description

Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.1,2 COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.3 In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.4

1 Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

2 Hoshi, K. Approved indications of lipo-PGE1 in Japan. Adv Drug Deliv Rev 20 171-176 (1996).

3 Samel, N., and Maxey, K.M. Personal Communication. (2003).

4 Kloeze, J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys Acta 187 285-292 (1969).

Synonyms
  • 1a,1b-dihomo PGE1
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​1a,​1b-​dihomo-​prost-​13E-​en-​1-​oic acid
Molecular Formula C22H38O5
Formula Weight 382.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCC(O)​/C=C/[C@H]​1C(O)​CC(=O)​C1CCCCCCCCC(=O)​O
InCHI Code
Copy InCHI code to clipboard
​1S/C22H38O5/c1-2-3-8-11-17(23)​14-15-19-18(20(24)​16-21(19)​25)​12-9-6-4-5-7-10-13-22(26)​27/h14-15,17-19,21,23,25H,2-13,16H2,1H3,(H,26,27)​/b15-14+/t17-,18+,19+,21+/m0/s1
InCHI Key
Copy InCHI key to clipboard
YMDDELUTDBQEMT-QZCLESEGSA-N

Download free InCHI Key generation software

1a,1b-dihomo Prostaglandin E1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
Bulk Contact
Cart Total $0.00

Please Login or Register to use this page.

Pricing updated 2014-04-19. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Adrenic Acid
Prostaglandin A1 methyl ester Exclusive
Prostaglandin E1

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · Experimental Biology 2014 · San Diego, California · April 26-30, 2014 · Booth 323
Other Resources
About Cayman Management Team Company Profile ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map Conference Travel Grants

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2014 Cayman Chemical Company

Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research · Buy now! · Analytical testing services and custom synthesis also available

Lost password?