Cayman Chemical Item Number 13122
CT 99021 (CAS 252917-06-9)
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a key inhibitory role in both the insulin and Wnt signaling pathways.1,2 CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.3 When tested against twenty different protein kinases, this inhibitor shows greater than 500-
Sutherland, C., Leighton, I.A., and Cohen, P. Inactivation of glycogen synthase kinase 3β by phosphorylation: New kinase connections in insulin and growth-
Papkoff, J., and Aikawa, M. WNT-
3. Ring, D.B., Johnson, K.W., Henriksen, E.J., et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52(3) 588-95 (2003).
Li, W., Zhou, H., Abujarour, R., et al. Generation of human-
Ying, Q., Wray, J., Nichols, J., et al. The ground state of embryonic stem cell self-
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CHIR99021 is available in the following screening library:
Pricing updated 2015-04-20. Prices are subject to change without notice.
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