CAY10589 Exclusive

Cayman Chemical Item Number 13164

(CAS 1077626-52-8)

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Description

Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. CAY10589 is a dual inhibitor of mPGES-1 (IC50 = 1.3 μM) and 5-LO (IC50 = 1.0 μM).1 It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.1

1. Koeberle, A., Zettl, H., Greiner, C., et al. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. J Med Chem 51 8068-8076 (2008).

Formal Name 2-​[[4-​[([1,​1’-​biphenyl]-​4-​ylmethyl)amino]-​6-​chloro-​2-​pyrimidinyl]thio]-​octanoic acid
CAS Number 1077626-52-8
Molecular Formula C25H28ClN3O2S
Formula Weight 470.0
Formulation A crystalline solid
Purity ≥98%
λmax 254 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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ClC1=CC(NCC2=CC=C(C3=CC=CC=C3)​C=C2)​=NC(SC(C(O)​=O)​CCCCCC)​=N1
InCHI Code
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​1S/C25H28ClN3O2S/c1-2-3-4-8-11-21(24(30)​31)​32-25-28-22(26)​16-23(29-25)​27-17-18-12-14-20(15-13-18)​19-9-6-5-7-10-19/h5-7,9-10,12-16,21H,2-4,8,11,17H2,1H3,(H,30,31)​(H,27,28,29)​
InCHI Key
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FQMPYBCEABTPIK-UHFFFAOYSA-N

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CAY10589 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00
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Pricing updated 2015-04-17. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

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