CAY10589 (CAS 1077626-52-8) (Inchi key FQMPYBCEABTPIK-UHFFFAOYSA-N) || Cayman Chemical | Supplier
CAY10589
Item № 13164
CAS № 1077626-52-8
Purity ≥98%
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1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00

Pricing updated 2015-08-28. Prices are subject to change without notice.

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Description

Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. CAY10589 is a dual inhibitor of mPGES-1 (IC50 = 1.3 μM) and 5-LO (IC50 = 1.0 μM).1 It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.1

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Technical Information
Formal Name 2-​[[4-​[([1,​1’-​biphenyl]-​4-​ylmethyl)amino]-​6-​chloro-​2-​pyrimidinyl]thio]-​octanoic acid
CAS Number 1077626-52-8
Molecular Formula C25H28ClN3O2S
Formula Weight 470.0
Purity ≥98%
Formulation A crystalline solid
λmax 254 nm
SMILES ClC1=CC(NCC2=CC=C(C3=CC=CC=C3)​C=C2)​=NC(SC(C(O)​=O)​CCCCCC)​=N1
InChI Code ​1S/C25H28ClN3O2S/c1-2-3-4-8-11-21(24(30)​31)​32-25-28-22(26)​16-23(29-25)​27-17-18-12-14-20(15-13-18)​19-9-6-5-7-10-19/h5-7,9-10,12-16,21H,2-4,8,11,17H2,1H3,(H,30,31)​(H,27,28,29)​
InChI Key FQMPYBCEABTPIK-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 107 Kb PDF

Download Safety Data Sheet (SDS) 22 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Koeberle, A., Zettl, H., Greiner, C., et al. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. J Med Chem 51 8068-8076 (2008).

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