FKGK 11
Item № 13179
CAS № 1071000-98-0
Purity ≥98%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
500 µg $36.00 $0.00
1 mg $68.00 $0.00
5 mg $288.00 $0.00
10 mg $504.00 $0.00

Pricing updated 2015-09-04. Prices are subject to change without notice.

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Description

Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid as products. There are three broad classes of PLA2, secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2), that have different functions. FKGK 11 is a selective inhibitor of iPLA2 that demonstrates an XI(50) value of 0.0073, where XI(50) equals the mole fraction of FKGK 11 in the total substrate interface required to inhibit iPLA2 by 50%.1 In comparison, mole fractions as high as 0.091 do not inhibit cPLA2 activity and cause only slight inhibition of sPLA2.1

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Technical Information
Formal Name 1,​1,​1,​2,​2-​pentafluoro-​7-​phenyl-​3-​heptanone
CAS Number 1071000-98-0
Molecular Formula C13H13F5O
Formula Weight 280.2
Purity ≥98%
Formulation A solution in ethanol
SMILES O=C(C(F)​(F)​C(F)​(F)​F)​CCCCC1=CC=CC=C1
InChI Code ​1S/C13H13F5O/c14-12(15,13(16,17)​18)​11(19)​9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2
InChI Key ROPVXAWEVYWEQY-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 111 Kb PDF

Download Safety Data Sheet (SDS) 34 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Baskakis, C., Magrioti, V., Cotton, N., et al. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem 51 8027-8037 (2008).

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