FKGK 11

Cayman Chemical Item Number 13179

(CAS 1071000-98-0)

FKGK 11 (CAS 1071000-98-0)

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Description

Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid as products. There are three broad classes of PLA2, secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2), that have different functions. FKGK 11 is a selective inhibitor of iPLA2 that demonstrates an XI(50) value of 0.0073, where XI(50) equals the mole fraction of FKGK 11 in the total substrate interface required to inhibit iPLA2 by 50%.1 In comparison, mole fractions as high as 0.091 do not inhibit cPLA2 activity and cause only slight inhibition of sPLA2.1

1 Baskakis, C., Magrioti, V., Cotton, N., et al. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem 51 8027-8037 (2008).

Formal Name 1,​1,​1,​2,​2-​pentafluoro-​7-​phenyl-​3-​heptanone
CAS Number 1071000-98-0
Molecular Formula C13H13F5O
Formula Weight 280.2
Formulation A solution in ethanol
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(C(F)​(F)​C(F)​(F)​F)​CCCCC1=CC=CC=C1
InCHI Code
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​1S/C13H13F5O/c14-12(15,13(16,17)​18)​11(19)​9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2
InCHI Key
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ROPVXAWEVYWEQY-UHFFFAOYSA-N

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FKGK 11 is available in the following screening library:

Size Price Quantity Subtotal
500 µg $36.00 $0.00
1 mg $68.00 $0.00
5 mg $288.00 $0.00
10 mg $504.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-23. Prices are subject to change without notice.

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