Cardiogenol C (hydrochloride)

Cayman Chemical Item Number 13187

(CAS 671225-39-1)

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Description

Most tissues have an endogenous pool of progenitor cells to draw from upon injury. The adult heart, however, contains a limited number of undifferentiated cells and techniques to replicate these cells from other pluripotent tissues have thus far been nonselective and inefficient. Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM.1 About 90% of embryonic stem cells treated with 0.25 µM cardiogenol C express the cardiac muscle cell specific transcription factors GATA-4, MEF2, and Nkx2.5 and display the characteristic beating behavior of differentiated cardiomyocytes.1

1. Wu, X., Ding, S., Ding, Q., et al. Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc 126(6) 1590-1591 (2004).

Formal Name 2-​[[2-​[(4-​methoxyphenyl)amino]-​4-​pyrimidinyl]amino]-​ethanol
CAS Number 671225-39-1
Molecular Formula C13H16N4O2 • HCl
Formula Weight 296.8
Formulation A crystalline solid
Purity ≥97%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COC1=CC=C(NC2=NC(NCCO)​=CC=N2)​C=C1.Cl
InCHI Code
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​1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)​16-13-15-7-6-12(17-13)​14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17)​;1H
InCHI Key
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QQAHYSZVJLHCNA-UHFFFAOYSA-N

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Cardiogenol C (hydrochloride) is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $25.00 $0.00
5 mg $113.00 $0.00
10 mg $138.00 $0.00
50 mg $563.00 $0.00
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