CAY10594 (CAS 1130067-34-3) (Inchi key FAIFAFUXFFWVNQ-UHFFFAOYSA-N) || Cayman Chemical | Supplier
CAY10594
Item № 13207
CAS № 1130067-34-3
Purity ≥98%
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CART TOTAL $0.00
1 mg $40.00 $0.00
5 mg $180.00 $0.00
10 mg $320.00 $0.00
25 mg $700.00 $0.00

Pricing updated 2015-08-31. Prices are subject to change without notice.

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Description

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles. CAY10594 is a potent PLD2 inhibitor, both in vitro (IC50 = 140 nM) and in cells (IC50 = 110 nM).1 It is also effective as a PLD1 inhibitor at higher concentrations (IC50 = 5.1 μM in vitro, 1.0 μM in cells).1 CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays,1 suggesting that PLD might be a useful target in blocking tumor cell invasion.

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Technical Information
Formal Name N-​[2-​(4-​oxo-​1-​phenyl-​1,​3,​8-​triazaspiro[4,​5]dec-​8-​yl)ethyl]-​2-​naphthalenecarboxamide
CAS Number 1130067-34-3
Molecular Formula C26H28N4O2
Formula Weight 428.5
Purity ≥98%
Formulation A crystalline solid
SMILES O=C(NCCN1CCC2(C(NCN2C3=CC=CC=C3)​=O)​CC1)​C4=CC(C=CC=C5)​=C5C=C4
InChI Code ​1S/C26H28N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)​18-22)​27-14-17-29-15-12-26(13-16-29)​25(32)​28-19-30(26)​23-8-2-1-3-9-23/h1-11,18H,12-17,19H2,(H,27,31)​(H,28,32)​
InChI Key FAIFAFUXFFWVNQ-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 111 Kb PDF

Download Safety Data Sheet (SDS) 25 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol 5(2) 108-117 (2009).

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