FTY720 phenoxy-biotin (Inchi key GZMFMKCTYQRSAN-MNRXJBBMSA-N) || Cayman Chemical | Supplier
FTY720 phenoxy-biotin
Item № 13254
Purity ≥95%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
100 µg $26.00 $0.00
500 µg $117.00 $0.00
1 mg $208.00 $0.00
5 mg $910.00 $0.00

Pricing updated 2015-08-29. Prices are subject to change without notice.

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Description

FTY720 is an immune modulator that down-regulates sphingosine-1-phosphate (S1P) receptors,1 enhances the activity of the sphingosine transporter ABCB1 and the leukotriene C4 transporter ABCC12 and inhibits cytosolic phospholipase A2 activity.3 It is known that some of the effects of FTY720 require its phosphorylation by sphingosine kinases in vivo, with FTY720-phosphate binding to and down-regulating S1P receptors. Biotin-FTY720 is a biotin-tagged analog of FTY720. The hydroxy methyl side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained in this analog, suggesting that it would likewise be phosphorylated in vivo.

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Technical Information
Formal Name 2-​amino-​2-​[2-​(4-​octylphenyl)ethyl]-​1,​3-​propanediol-​N-​biotinoyl-​1,​5-​diampentane
Molecular Formula C27H44N4O5S · HCl
Formula Weight 573.2
Purity ≥95%
Formulation A solution in ethanol
SMILES OCC(N)​(CO)​CCC1=CC=C(OCCCCCCNC(CCCC[C@H]​2SC[C@]​(N3)​([H]​)​[C@@]​2([H]​)​NC3=O)​=O)​C=C1.Cl
InChI Code ​1S/C27H44N4O5S.ClH/c28-27(18-32,19-33)​14-13-20-9-11-21(12-10-20)​36-16-6-2-1-5-15-29-24(34)​8-4-3-7-23-25-22(17-37-23)​30-26(35)​31-25;/h9-12,22-23,25,32-33H,1-8,13-19,28H2,(H,29,34)​(H2,30,31,35)​;1H/t22-,23-,25-;/m1./s1
InChI Key GZMFMKCTYQRSAN-MNRXJBBMSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
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Download Product Insert 130 Kb PDF

Download Safety Data Sheet (SDS) 28 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Brinkmann, V., Davis, M.D., Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24) 21453-21457 (2002).

2. Honig, S.M., Fu, S., Mao, X., et al. FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. J Clin Invest 111(5) 627-637 (2003).

3. Payne, S.G., Oskeritizian, C.A., Griffiths, R., et al. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 109(3) 1077-1085 (2007).

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