AG-126

Cayman Chemical Item Number 13297

Tyrphostin AG-126 (CAS 118409-62-4)

See more

Description

Tyrphostins are a family of protein tyrosine kinase inhibitors originally developed to inhibit cell growth by blocking the activity of certain growth factor receptor kinases (GFRK). The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.1,2 It blocks the production of TNF-α in vitro2 and in vivo,1 attenuating signaling through NF-κB,1 the induced expression of COX-2 and iNOS,3,4 and the inflammatory response in diverse animal models.3,5 AG-126 is a poor inhibitor of epidermal GFRK (IC50 = 450 μM)6 and platelet-derived GFRK (IC50 > 100 μM).7

1. Novogrodsky, A., Vanichkin, A., Patya, M., et al. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264(5163) 1319-1322 (1994).

2. Hanisch, U., Prinz, M., Angstwurm, K., et al. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur J Immunol 31 2104-2115 (2001).

3. Cuzzocrea, S., McDonald, M.C., Mazzon, E., et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol 157(1) 145-158 (2000).

4. Ruetten, H., and Thiemermann, C. Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: A possible role for protein tyrosine kinase. Br J Pharmacol 122 59-70 (1997).

5. Chatterjee, P.K., Patel, N.S.A., Kvale, E.O., et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat. Kidney Int 64 1605-1619 (2003).

6. Gazit, A., Yaish, P., Gilon, C., et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32(10) 2344-2352 (1989).

7. Sagara, Y., Ishige, K., Tsai, C., et al. Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem 277(39) 36204-36215 (2002).

Synonyms
  • Tyrphostin AG-126
Formal Name 2-​[(3-​hydroxy-​4-​nitrophenyl)methylene]-​propanedinitrile
CAS Number 118409-62-4
Molecular Formula C10H5N3O3
Formula Weight 215.2
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
OC1=C([N+]​([O-]​)​=O)​C=CC(/C=C(C#N)​\C#N)​=C1
InCHI Code
Copy InCHI code to clipboard
​1S/C10H5N3O3/c11-5-8(6-12)​3-7-1-2-9(13(15)​16)​10(14)​4-7/h1-4,14H
InCHI Key
Copy InCHI key to clipboard
DUQADSPERJRQBW-UHFFFAOYSA-N

Download free InCHI Key generation software

AG-126 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $25.00 $0.00
5 mg $75.00 $0.00
10 mg $138.00 $0.00
25 mg $313.00 $0.00
Bulk Contact
Cart Total $0.00

Bulk Inquiry Form:

Thank you for requesting a bulk size for this product.










X

Enter number, size, and select unit. Example: 2 x 500 mg




Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

Pricing updated 2015-04-27. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

AG-1024
AG-1296
AG-1478
AG-370
AG-490
AG-808 New
AG-82
AG-825
AG-879
AG-957 New
SU 6668
Show all 11 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...

Lost password?