Bisindolylmaleimide I

Cayman Chemical Item Number 13298

BIM I; GF 109203X; Gö 6850 (CAS 133052-90-1)

See more


Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine.1 It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα-, β1-, β2-, γ-, δ-, and ε-isozymes.1 BIM I directly inhibits GSK3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM).2 This compound also competitively antagonizes the 5-HT3 receptor with a Ki value of 61 nM.3

1. Toullec, D., Pianetti, P., Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266(24) 15771-15781 (1991).

2. Hers, I., Tavaré, J.M., and Denton, R.M. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett 460 433-436 (1999).

3. Coultrap, S.J., Sun, H., Tenner, T.E., et al. Competitive antagonism of the mouse 5-hydroxytryptamine receptor by bisindolylmaleimide I, a “selective” protein kinase C inhibitor. J Pharmacol Exp Ther 290(1) 76-82 (1999).

  • BIM I
  • GF 109203X
  • Gö 6850
Formal Name 3-​[1-​[3-​(dimethylamino)propyl]-​1H-​indol-​3-​yl]-​4-​(1H-​indol-​3-​yl)-​1H-​pyrrole-​2,​5-​dione
CAS Number 133052-90-1
Molecular Formula C25H24N4O2
Formula Weight 412.5
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Copy SMILES to clipboard
InCHI Code
Copy InCHI code to clipboard
Copy InCHI key to clipboard

Download free InCHI Key generation software

Size Price Quantity Subtotal
5 mg $69.00 $0.00
10 mg $131.00 $0.00
25 mg $311.00 $0.00
50 mg $552.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

AZD 1080​
AZD 2858​
Bisindolylmaleimide II
Bisindolylmaleimide IV
Bisindolylmaleimide IX (mesylate)
Bisindolylmaleimide V
Bisindolylmaleimide VIII (acetate)
Bisindolylmaleimide X (hydrochloride)
Bisindolylmaleimide XI (hydrochloride)
Calphostin C
HA-100 (hydrochloride)
Palonosetron (hydrochloride​)
PKCα (C2-4) Inhibitor Peptide
Show all 16 Hide all but first 3


Batch-specific Information

Get batch-specific data and documents by batch number

Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


Please wait...