Gö 6983

Cayman Chemical Item Number 13311

(CAS 133053-19-7)

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Gö 6983 inhibits several isoforms of protein kinase C (PKC; IC50 = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively).1 It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.2,3

1. Gschwendt, M., Dieterich, S., Rennecke, J., et al. Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett 392 77-80 (1996).

2. Peterman, E.E., Taormina, P.I., Harvey, M., et al. Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol 43 645-656 (2004).

3. Young, L.H., Balin, B.J., and Weis, M.T. Gö 6983: A fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev 23(3) 255-272 (2005).

Formal Name 3-​[1-​[3-​(dimethylamino)propyl]-​5-​methoxy-​1H-​indol-​3-​yl]-​4-​(1H-​indol-​3-​yl)-​1H-​pyrrole-​2,​5-​dione
CAS Number 133053-19-7
Molecular Formula C26H26N4O3
Formula Weight 442.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $35.00 $0.00
5 mg $120.00 $0.00
10 mg $180.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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