Gö 6983

Cayman Chemical Item Number 13311

(CAS 133053-19-7)

Gö 6983 (CAS 133053-19-7)

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Description

Gö 6983 inhibits several isoforms of protein kinase C (PKC; IC50 = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively).1 It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.2,3

1 Gschwendt, M., Dieterich, S., Rennecke, J., et al. Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett 392 77-80 (1996).

2 Peterman, E.E., Taormina, P.I., Harvey, M., et al. Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol 43 645-656 (2004).

3 Young, L.H., Balin, B.J., and Weis, M.T. Gö 6983: A fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev 23(3) 255-272 (2005).

Formal Name 3-​[1-​[3-​(dimethylamino)propyl]-​5-​methoxy-​1H-​indol-​3-​yl]-​4-​(1H-​indol-​3-​yl)-​1H-​pyrrole-​2,​5-​dione
CAS Number 133053-19-7
Molecular Formula C26H26N4O3
Formula Weight 442.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc2n(CCCN(C)​C)​cc(C3=C(C(=O)​NC3=O)​c3c[nH]​c4ccccc34)​c2c1
InCHI Code
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​1S/C26H26N4O3/c1-29(2)​11-6-12-30-15-20(18-13-16(33-3)​9-10-22(18)​30)​24-23(25(31)​28-26(24)​32)​19-14-27-21-8-5-4-7-17(19)​21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)​
InCHI Key
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LLJJDLHGZUOMQP-UHFFFAOYSA-N

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Gö 6983 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $35.00 $0.00
5 mg $120.00 $0.00
10 mg $180.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-19. Prices are subject to change without notice.

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