Cayman Chemical Item Number 13311
Gö 6983 inhibits several isoforms of protein kinase C (PKC; IC50 = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively).1 It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.2,3
1. Gschwendt, M., Dieterich, S., Rennecke, J., et al. Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett 392 77-80 (1996).
2. Peterman, E.E., Taormina, P.I., Harvey, M., et al. Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol 43 645-656 (2004).
3. Young, L.H., Balin, B.J., and Weis, M.T. Gö 6983: A fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev 23(3) 255-272 (2005).
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Gö 6983 is available in the following screening libraries:
Pricing updated 2015-08-02. Prices are subject to change without notice.
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