Cayman Chemical Item Number 13314

(CAS 160807-49-8)

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Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 22 nM).1 As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer’s disease-relevant sites.1 It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC50 = 180 nM), Cdk2/cyclin A (IC50 ~500 nM), Cdk2/cyclin E (IC50 = 250nM), Cdk4/cyclin D1 (IC50 = 3.3 µM) and Cdk5/p35 (IC50 = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.2,3

1. LeClerc, S., Garnier, M., Hoessel, R., et al. Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem 276(1) 251-260 (2001).

2. Damiens, E., Baratte, B., Marie, D., et al. Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: Induction of endoreplication following prophase arrest. Oncogene 20 3786-3797 (2001).

3. Marko, D., Schätzle, S., Friedel, A., et al. Inhibition of cyclin-dependent kinase 1 (CDK1) byindirubin derivatives in human tumour cells. Br J Cancer 84(2) 283-289 (2001).

Formal Name 3-​[1,​3-​dihydro-​3-​(hydroxyimino)-​2H-​indol-​2-​ylidene]-​1,​3-​dihydro-​2H-​indol-​2-​one
CAS Number 160807-49-8
Molecular Formula C16H11N3O2
Formula Weight 277.3
Formulation A crystalline solid
Purity ≥98%
λmax 212, 252, 280, 286, 328, 342, 502 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $38.00 $0.00
5 mg $76.00 $0.00
10 mg $133.00 $0.00
50 mg $570.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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