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Join us! · ENDO 2015 · San Diego, California · March 5-8, 2015 · Booth 1935
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Cayman is a manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research. Analytical testing services and custom synthesis are also available.

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2015 Cayman Chemical Company

IM-54

Cayman Chemical Item Number 13323

(CAS 861891-50-1)

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Description

IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells.1 It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase 1.1

1. Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorg Med Chem Lett 15(12) 3114-3118 (2005).

Formal Name 1-​methyl-​3-​(1-​methyl-​1H-​indol-​3-​yl)-​4-​(pentylamino)-​1H-​pyrrole-​2,​5-​dione
CAS Number 861891-50-1
Molecular Formula C19H23N3O2
Formula Weight 325.4
Formulation A crystalline solid
Purity ≥95%
λmax 206, 227, 289, 404 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCNC1=C(C(=O)​N(C)​C1=O)​c1cn(C)​c2ccccc12
InCHI Code
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​1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)​22(3)​19(17)​24)​14-12-21(2)​15-10-7-6-9-13(14)​15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3
InCHI Key
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SGLOMINNEBLJFF-UHFFFAOYSA-N

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Background Reading

Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorg Med Chem Lett 15(12) 3114-3118 (2005).

IM-54 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $24.00 $0.00
5 mg $108.00 $0.00
10 mg $192.00 $0.00
25 mg $420.00 $0.00
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Cart Total $0.00

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Pricing updated 2015-03-06. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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