IM-54

Cayman Chemical Item Number 13323

(CAS 861891-50-1)

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Description

IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells.1 It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase 1.1

1. Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorg Med Chem Lett 15(12) 3114-3118 (2005).

Formal Name 1-​methyl-​3-​(1-​methyl-​1H-​indol-​3-​yl)-​4-​(pentylamino)-​1H-​pyrrole-​2,​5-​dione
CAS Number 861891-50-1
Molecular Formula C19H23N3O2
Formula Weight 325.4
Formulation A crystalline solid
Purity ≥95%
λmax 206, 227, 289, 404 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCNC1=C(C(=O)​N(C)​C1=O)​c1cn(C)​c2ccccc12
InCHI Code
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​1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)​22(3)​19(17)​24)​14-12-21(2)​15-10-7-6-9-13(14)​15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3
InCHI Key
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SGLOMINNEBLJFF-UHFFFAOYSA-N

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Background Reading

Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorg Med Chem Lett 15(12) 3114-3118 (2005).

IM-54 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $24.00 $0.00
5 mg $108.00 $0.00
10 mg $192.00 $0.00
25 mg $420.00 $0.00
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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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