IM-54 (CAS 861891-50-1) (Inchi key SGLOMINNEBLJFF-UHFFFAOYSA-N) || Cayman Chemical | Supplier
IM-54
Item № 13323
CAS № 861891-50-1
Purity ≥95%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
1 mg $24.00 $0.00
5 mg $108.00 $0.00
10 mg $192.00 $0.00
25 mg $420.00 $0.00

Pricing updated 2015-08-29. Prices are subject to change without notice.

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Description

IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells.1 It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase 1.1

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Technical Information
Formal Name 1-​methyl-​3-​(1-​methyl-​1H-​indol-​3-​yl)-​4-​(pentylamino)-​1H-​pyrrole-​2,​5-​dione
CAS Number 861891-50-1
Molecular Formula C19H23N3O2
Formula Weight 325.4
Purity ≥95%
Formulation A crystalline solid
λmax 206, 227, 289, 404 nm
SMILES CCCCCNC1=C(C(=O)​N(C)​C1=O)​c1cn(C)​c2ccccc12
InChI Code ​1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)​22(3)​19(17)​24)​14-12-21(2)​15-10-7-6-9-13(14)​15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3
InChI Key SGLOMINNEBLJFF-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 105 Kb PDF

Download Safety Data Sheet (SDS) 24 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorg Med Chem Lett 15(12) 3114-3118 (2005).

Background Reading

Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorg Med Chem Lett 15(12) 3114-3118 (2005).

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