Bisindolylmaleimide IX (mesylate)

Cayman Chemical Item Number 13334

Ro 31-8220; BIM IX (CAS 138489-18-6)

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Bisindolylmaleimide IX (BIM IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively).1 It is a poor inhibitor of protein kinase A (PKA, IC50 = 0.9 μM) and calcium/calmodulin kinase II (IC50 = 17 μM). BIM IX also inhibits glycogen synthase kinase 3 (IC50 = 6.8 nM).2

1. Wilkinson, S.E., Parker, P.J., and Nixon, J.S. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294 335-337 (1993).

2. Hers, I., Tavaré, J.M., and Denton, R.M. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett 460 433-436 (1999).

  • Ro 31-8220
  • BIM IX
Formal Name 3-​[3-​[2,​5-​dihydro-​4-​(1-​methyl-​1H-​indol-​3-​yl)-​2,​5-​dioxo-​1H-​pyrrol-​3-​yl]-​1H-​indol-​1-​yl]propyl ester-​methanesulfonate,​ carbamimidothioic acid
CAS Number 138489-18-6
Molecular Formula C25H23N5O2S • CH3SO3H
Formula Weight 553.7
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Bisindolylmaleimide IX (mesylate) is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $35.00 $0.00
5 mg $135.00 $0.00
10 mg $199.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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