Bisindolylmaleimide IX (mesylate)

Cayman Chemical Item Number 13334

Ro 31-8220; BIM IX (CAS 138489-18-6)

Bisindolylmaleimide IX (mesylate) (CAS 138489-18-6)

See more

Description

Bisindolylmaleimide IX (BIM IX) is a potent, cell-permeable BIM inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively).1 It is a poor inhibitor of protein kinase A (PKA, IC50 = 0.9 μM) and calcium/calmodulin kinase II (IC50 = 17 μM). BIM IX also inhibits glycogen synthase kinase 3 (IC50 = 6.8 nM).2

1 Wilkinson, S.E., Parker, P.J., and Nixon, J.S. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294 335-337 (1993).

2 Hers, I., Tavaré, J.M., and Denton, R.M. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett 460 433-436 (1999).

Synonyms
  • Ro 31-8220
  • BIM IX
Formal Name 3-​[3-​[2,​5-​dihydro-​4-​(1-​methyl-​1H-​indol-​3-​yl)-​2,​5-​dioxo-​1H-​pyrrol-​3-​yl]-​1H-​indol-​1-​yl]propyl ester-​methanesulfonate,​ carbamimidothioic acid
CAS Number 138489-18-6
Molecular Formula C25H23N5O2S · CH3SO3H
Formula Weight 553.7
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C(N1[H]​)​C(C2=CN(C)​C3=C2C=CC=C3)​=C(C4=CN(CCCS/C(N)​=N\[H]​)​C5=C4C=CC=C5)​C1=O.CS(=O)​(O)​=O
InCHI Code
Copy InCHI code to clipboard
​1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)​29)​21-22(24(32)​28-23(21)​31)​18-14-30(11-6-12-33-25(26)​27)​20-10-5-3-8-16(18)​20;1-5(2,3)​4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)​(H,28,31,32)​;1H3,(H,2,3,4)​
InCHI Key
Copy InCHI key to clipboard
SAWVGDJBSPLRRB-UHFFFAOYSA-N

Download free InCHI Key generation software

Bisindolylmaleimide IX (mesylate) is available in the following screening library:

Size Price Quantity Subtotal
1 mg $35.00 $0.00
5 mg $135.00 $0.00
10 mg $199.00 $0.00
Bulk Contact
Cart Total $0.00

Please Login or Register to use this page.

Pricing updated 2014-04-23. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Bisindolylmaleimide I
Bisindolylmaleimide IV
Bisindolylmaleimide V
Bisindolylmaleimide VIII (acetate)
Bisindolylmaleimide XI (hydrochloride)
Chelerythrine chloride
Show all 6 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · Experimental Biology 2014 · San Diego, California · April 26-30, 2014 · Booth 323 Join us! · ASPET Symposium 2014: Scientists versus Street Chemists: The Toxicity of Designer Marijuana · San Diego, California · April 30, 2014
Other Resources
About Cayman Management Team Company Profile ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map Conference Travel Grants

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2014 Cayman Chemical Company

Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research · Buy now! · Analytical testing services and custom synthesis also available

Lost password?