Cayman Chemical Item Number 13337

(CAS 107761-24-0)

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ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.1,2,3

1. Fuortes, M., Jin, W., and Nathan, C. Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J Cell Biol 120(3) 777-784 (1993).

2. Murasawa, S., Mori, Y., Nozawa, Y., et al. Role of calcium-sensitive tyrosine kinase Pyk2/CAKβ/RAFTK in angiotensin II-induced Ras/ERK signaling. Hypertension 32 668-675 (1998).

3. Takemasa, H., Imagawa, N., Kawakami-Honda, N., et al. Effect of phosphotyrosine proteins on phorbol myristate acetate-induced NADPH oxidase activation in guinea pig peritoneal polymorphonuclear leukocytes. Biol Pharm Bull 26(7) 1009-1012 (2003).

Formal Name 2-​cyano-​3-​[3-​ethoxy-​4-​hydroxy-​5-​[(5-​phenylthio)methyl]phenyl]-​2-​propenamide
CAS Number 107761-24-0
Molecular Formula C19H18N2O3S
Formula Weight 354.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $30.00 $0.00
5 mg $135.00 $0.00
10 mg $240.00 $0.00
25 mg $525.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-30. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


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