GYY 4137

Cayman Chemical Item Number 13345

(CAS 106740-09-4)

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Description

Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor.1 When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models.1 Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.2

1. Li, L., Whiteman, M., Guan, Y.Y., et al. Characterization of a novel, water-soluble hydrogen sulfide releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide. Circulation 117 2351-2360 (2008).

2. Li, L., Salto-Tellez, M., Tan, C., et al. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic Biol Med 47 103-113 (2009).

Formal Name (p-​methoxyphenyl)morpholino-​phosphinodithioic acid
CAS Number 106740-09-4
Molecular Formula C11H16NO2PS2 • C4H10NO
Formula Weight 377.5
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(cc1)​P(=S)​([S-]​)​N1CCOCC1.C1COCC[NH2+]​1
InCHI Code
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​1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)​15(16,17)​12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17)​;5H,1-4H2
InCHI Key
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YZMHNNLDUWRZFW-UHFFFAOYSA-N

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Size Price Quantity Subtotal
10 mg $47.00 $0.00
25 mg $112.00 $0.00
50 mg $212.00 $0.00
100 mg $376.00 $0.00
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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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